Rheumatoid arthritis (RA) is a known chronic autoimmune disease can cause joint deformity and even loss of joint function. Fibroblast-like synoviocytes (FLS), one of the main cell types in synovial tissues of RA patients, are key effector cells in the development of RA and are considered as promising therapeutic targets for treating RA. Herbal medicines are precious resources for finding novel agents for treating various diseases including RA. It is reported that induction of apoptosis in FLS is an important mechanism for the herbal medicines to treat RA. Consequently, this paper reviewed the current available references on pro-apoptotic effects of herbal medicines on FLS and summarized the related possible signal pathways. Taken together, the main related signal pathways are concluded as death receptors mediated apoptotic pathway, mitochondrial dependent apoptotic pathway, NF-κB mediated apoptotic pathways, mitogen-activated protein kinase (MAPK) mediated apoptotic pathway, endoplasmic reticulum stress (ERS) mediated apoptotic pathway, PI3K-Akt mediated apoptotic pathway, and other reported pathways such as janus kinase/signal transducers and activators of transcription (JAK-STAT) signal pathway. Understanding the apoptosis induction pathways in FLS of these herbal medicines will not only help clear molecular mechanisms of herbal medicines for treating RA but also be beneficial for finding novel candidate therapeutic drugs from natural herbal medicines. Thus, we expect the present review will highlight the importance of herbal medicines and its components for treating RA via induction of apoptosis in FLS, and provide some directions for the future development of these mentioned herbal medicines as anti-RA drugs in clinical.
In the hinterland of the desert, valuable archives of paleoenvironmental evolution are scarce. Calcareous root tubes (CRTs) have a strong potential for reconstructing paleoenvironmental conditions. It is still unclear, however, whether chemical elements in the CRTs can provide insights into paleoenvironmental conditions. In this study, the major- and trace-element composition of 32 CRT samples from the Alashan Desert were analyzed by X-ray fluorescence spectrometry. Results showed that the elemental composition and content change were controlled by the parent material and climatic conditions at the time of CRT formation. Ca, Mg, and Sr were significantly affected by climate, whereas the enrichment of P is likely related to the growth of plants. Higher (lower) Mg/Ca and Sr/Ca ratios corresponded to higher (lower) effective moisture and a higher (lower) Mg/Sr ratio indicated a higher (lower) temperature during the middle Holocene (8–5 cal ka BP). The reconstruction results for effective moisture were consistent with those in the Asian monsoon margin of northwestern China, which were caused by higher monsoon precipitation and lower evaporation. Therefore, chemical elements in the CRTs can reflect changes in paleo-effective moisture and paleotemperature at a millennial resolution in this area.
Rheum palmatum
L. (RPL) is a known traditional herbal medicine with the functions of “
heat-clearing and damp-drying
” in traditional Chinese medicine. Its anti-cancer effect against lung cancer has been confirmed previously, but the related mechanisms and active substances for its action has been little studied. This study adopted the network pharmacology, built the network map of drug ingredients and disease targets (DDN), and discussed the effective components of RPL and its possible mechanisms. All constituents of RPL were collected through database search and literature mining, and the potential active constituents were screened. The inverse pharmacophore matching model was used to predict the targets of active ingredients, and the method was supplemented by database retrieval and literature mining. Compounds-target data were inputted into Cytoscape software to build the DDN of RPL, and functional annotation analysis and pathway enrichment analysis were carried out. Finally, 20 active compounds were screened, which acted on 817 targets. A total of 22,418 lung cancer-related targets were collected, and 761 overlapped with drug targets. By bioinformatics annotation of these overlapping genes, a total of 235 gene ontology (GO) functional annotation analyses and 46 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were obtained. It was found that the enrichment of GO and KEGG was associated with apoptosis, suggesting RPL plays an anti-lung cancer role
via
inducing cell apoptosis. Subsequent cell experiment results showed RPL and its active constituents inhibited the proliferation of A549 cells and reduced clone formation rate of A549 cells
via
induction of apoptosis. In this study, the pharmacodynamic basis and mechanism of RPL against lung cancer were studied from the perspective of systematic pharmacology, which would be beneficial for further elucidating the anticancer effect of RPL on lung cancer.
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