Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis

Duan, Hu-Xinyue; Zhang, Qing; Liu, Jia; Li, Ruolan; Wang, Dan; Peng, Wei; Wu, Chunjie

doi:10.1016/j.phrs.2021.105599

Cited by 125 publications

(76 citation statements)

References 174 publications

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“…The tissue-protective effects of EPO following its anti-apoptotic properties have also been reported in rodent models of sepsis, using human recombinant EPO and its analogue (15,16). Numerous studies have shown that endothelial cells can undergo apoptosis in response to polymicrobial endotoxic shock (17,18). Endothelial apoptosis enhances exposure of negatively charged phospholipids, which are involved in factor VIIIa-and factor IXa-dependent activation of factor X on endothelial cells (19,20).…”

Section: Introductionmentioning

confidence: 92%

Recombinant human erythropoietin attenuates hepatic dysfunction by suppressing hepatocellular apoptosis in lipopolysaccharide‑induced disseminated intravascular coagulation in rats

et al. 2021

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Section: Introductionmentioning

confidence: 92%

Recombinant human erythropoietin attenuates hepatic dysfunction by suppressing hepatocellular apoptosis in lipopolysaccharide‑induced disseminated intravascular coagulation in rats

et al. 2021

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“…Vascular ECs constitute a huge divider separating the lumen and wall of the vessel, and therefore play a crucial role in maintaining the vascular function and microenvironment homeostasis. Especially, vascular EC apoptosis is a key process involved in the vascular physiological and pathophysiological regulation such as organ development, angiogenesis, vascular injury, and remodeling (Duan et al, 2021;Tisch and Ruiz de Al modóvar, 2021). During the development of hypoxic pulmonary artery structural remodeling, hypoxia-induced vascular EC apoptosis is a critical pathological change.…”

Section: Endogenous So 2 Inhibits Vascular Endothelial Cell Apoptosismentioning

confidence: 99%

Endogenous SO2 Controls Cell Apoptosis: The State-of-the-Art

Feng

et al. 2021

Front. Cell Dev. Biol.

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SO2, previously known as the product of industrial waste, has recently been proven to be a novel gasotransmitter in the cardiovascular system. It is endogenously produced from the metabolism pathway of sulfur-containing amino acids in mammalians. Endogenous SO2 acts as an important controller in the regulation of many biological processes including cardiovascular physiological and pathophysiological events. Recently, the studies on the regulatory effect of endogenous SO2 on cell apoptosis and its pathophysiological significance have attracted great attention. Endogenous SO2 can regulate the apoptosis of vascular smooth muscle cells, endothelial cells, cardiomyocytes, neuron, alveolar macrophages, polymorphonuclear neutrophils and retinal photoreceptor cells, which might be involved in the pathogenesis of hypertension, pulmonary hypertension, myocardial injury, brain injury, acute lung injury, and retinal disease. Therefore, in the present study, we described the current findings on how endogenous SO2 is generated and metabolized, and we summarized its regulatory effects on cell apoptosis, underlying mechanisms, and pathophysiological relevance.

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“…Apoptosis of vascular endothelial cells is caused by various factors, such as hyperglycemia and inflammation. Apoptosis induces tissue damage and affects the onset and exacerbation of disease [ 38 , 39 , 40 , 41 , 42 , 43 ]. On the other hand, it is also related to remodeling into a mature network during angiogenesis [ 44 ].…”

Section: Suppression Of Apoptosis By Rasgrp2 Signaling In the Vascular Endothelial Cellsmentioning

confidence: 99%

The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review

Takino

Miyazaki

Nagamine

et al. 2021

IJMS

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RAS guanyl nucleotide-releasing proteins (RASGRPs) are important proteins that act as guanine nucleotide exchange factors, which activate small GTPases and function as molecular switches for intracellular signals. The RASGRP family is composed of RASGRP1–4 proteins and activates the small GTPases, RAS and RAP. Among them, RASGRP2 has different characteristics from other RASGRPs in that it targets small GTPases and its localizations are different. Many studies related to RASGRP2 have been reported in cells of the blood cell lineage. Furthermore, RASGRP2 has also been reported to be associated with Huntington’s disease, tumors, and rheumatoid arthritis. In addition, we also recently reported RASGRP2 expression in vascular endothelial cells, and clarified the involvement of xenopus Rasgrp2 in the vasculogenesis process and multiple signaling pathways of RASGRP2 in human vascular endothelial cells with stable expression of RASGRP2. Therefore, this article outlines the existing knowledge of RASGRP2 and focuses on its expression and role in vascular endothelial cells, and suggests that RASGRP2 functions as a protective factor for maintaining healthy blood vessels.

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Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis

Cited by 125 publications

References 174 publications

Recombinant human erythropoietin attenuates hepatic dysfunction by suppressing hepatocellular apoptosis in lipopolysaccharide‑induced disseminated intravascular coagulation in rats

Recombinant human erythropoietin attenuates hepatic dysfunction by suppressing hepatocellular apoptosis in lipopolysaccharide‑induced disseminated intravascular coagulation in rats

Endogenous SO2 Controls Cell Apoptosis: The State-of-the-Art

The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review

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