In this research, Water Quality Index and Multivariate Statistics Techniques was carried out on fourteen water quality parameters collected quarterly (four times/year) from nine water sources in Agra, Uttar Pradesh, India for one year (May 2019- April 2020). The Water Quality Parameters (WQP) included are the concentration of hydrogen ion (pH), Electrical conductivity, Turbidity, Total dissolved solids (TDS), Total Hardness, Total Alkalinity, Calcium, Sulphate, Chloride, Magnesium, Iron, COD, DO, and BOD. The Water sample collected shows that the mean values of physicochemical parameters are in the range of WHO and BIS except for Hardness in summer (1,680 mg/L); monsoon (832.22 mg/L); winter (1,876.66 mg/L); spring (1,535.55 mg/L), TDS in summer (1,000.33 mg/L); monsoon (683.44 mg/L); winter (1,087.66 mg/L); spring (776.66 mg/L) and sulphate (927.22 mg/L); monsoon (446.77 mg/L); winter (925.77 mg/L); spring (944.88 mg/L) which indicate the bad quality of water. The WQI values were calculated for three locations at different weather conditions. WQI values in summer, winter and spring are 630.90, 279.61, 279.91 shows that river water is not suitable for drinking purpose whereas the WQI value in monsoon is 75.89 shows that water is fit for drinking purposes due to the dilution of river water. A moderate positive correlation was observed for turbidity with total hardness, iron, total alkalinity, and sulphate. Negative Correlation was observed with pH. Moderate Correlation was seen with TDS-EC (0.608), TDS-Alkalinity (0.7794), EC-Ca (0.723) and strong was observed for BOD-DO (0.941) and Ca-Mg (0.999). Principal Component Analysis revealed that five factors were significant (eigen value > 0.5) with total variance of 39.43%–85.19% respectively. The ICP-MS study of water sample from point source indicate the presence of Ni2+, Cr6+, Co2+, Mn2+, Cu2+, Zn2+ ions at higher concentrations.