-First spike latency following stimulus onset is of significant physiological relevance. Neurons transmit information about their inputs by transforming them into spike trains, and the timing of these spike trains is in turn crucial for effectively encoding that information. Random processes and uncertainty that underly neuronal dynamics have been shown to prolong the time towards the first response in a phenomenon dubbed noise-delayed decay. Here we study whether Hodgkin-Huxley neurons with a tunable intensity of intrinsic noise might have shorter response times to external stimuli just above threshold if placed on a scale-free network. We show that the heterogeneity of the interaction network may indeed eradicate slow responsiveness, but only if the coupling between individual neurons is sufficiently strong. Increasing the average degree also favors a fast response, but it is less effective than increasing the coupling strength. We also show that noise-delayed decay can be offset further by adjusting the frequency of the external signal, as well as by blocking a fraction of voltage-gated sodium or potassium ion channels. For certain conditions, we observe a double peak in the response time depending on the intensity of intrinsic noise, indicating competition between local and global effects on the neuronal dynamics.
ÖZET Son zamanlarda yaygın ve ayak taban siğili olan hastalara kriyoterapi ve immünoterapi tedavi yöntemleri uygulanmaya başlanmıştır. Bununla birlikte hangi tedavi yönteminin başarılı olacağına dair bir kanıt bulunmamaktadır. Bu çalışmada, bu iki yöntemin siğil tedavisinde başarılı olup olmayacağı lojistik regresyon ve karar ağacı algoritmaları kullanılarak tahmin edilmeye çalışılmıştır. Çalışmada açık erişime sahip olan UCI veri tabanındaki veriler kullanılarak WEKA yazılımı üzerinde algoritmalar koşturulmuştur. Sonuç olarak, seçilen siğil tedavi yönteminin başarısı karar ağacı sınıflandırıcısı ile %85,56 oranında doğru olarak tespit edilmiştir.
ABSTRACTRecently, treatment methods of cryotherapy and immunotherapy have been got off the ground to the patients with common and plantar warts. On the other hand, there is no proof of which treatment method will be successful, yet. In this study, it is tried to predict whether these two methods succeed on wart treatment or not using the logistic regression and the decision tree algorithms. These algorithms were run on WEKA software using data sets that are freely available from UCI databases in this study. As a result, the success of the selected wart treatment method was predicted with the accuracy of 85.56% by using the decision tree algorithm.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.