Effects of autapse and channel blockage on firing regularity in a biological neuronal network

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“…Experimental studies reveal that autapse is quite common, contrary to expectations (Lübke et al 1996, Bekkers 1998, Bacci and Huguenard 2006, Branco and Staras 2009, Flight 2009, Rusin et al 2011. Besides these experimental studies, numerical studies have shown that autaptic connections play important roles on the spiking dynamics of the neurons (Bacci and Huguenard 2006, Li et al 2010, Qin et al 2014, Yilmaz and Ozer 2015, Yilmaz et al 2015a, Yilmaz et al 2015b, Wang and Chen 2016, Wang and Gong 2016, Yilmaz et al 2016, Uzun and Ozer 2017a, Uzun and Ozer 2017b, Uzun et al 2017. For example, Li et al (2010) demonstrated that, at certain characteristic frequencies, the spiking dynamics of a single neuron are weakened by the delayed feedback which manifests itself by the occurrence of bursting firings and multimodal interspike interval distributions.…”

“…We reported that at different ion channel blocking levels, the spiking dynamics of the neuron do not change for too small coupling strength whether it increases after a certain coupling strength' value. Apart from these studies performed at single neuron level, there are also many studies conducted at neuronal networks modelled with different network structures in the literature (Qin et al 2014, Yilmaz et al 2015a, Yilmaz et al 2015b, Wang and Gong 2016, Uzun and Ozer 2017b, Uzun et al 2017.…”