Background: Liver diseases are associated with significant morbidity and mortality. Punica granatum may have free radical scavenging activity and it can be used for the prevention and treatment of liver damage. Objective: To observe the hepatoprotective effects of Punica granatum on CCl 4 induced liver damage in rats. Methods: The experimental study was carried out in the Dept of Physiology, Dhaka Medical Ccollege, Dhaka from July 2013 to June 2014. For this purpose, 36 wistar albino rats were studied. After acclimatization for 7 days, they were divided into two groups-control and experimental group. Control group were subdivided into BC (Baseline control), CC (CCl 4 treated control) and SC (Silymarin treated control). Experimental group were subdivided into CP-APT (CCl 4 pretreated and aqueous extract of pomegranate treated), CP-EPT (CCl 4 pretreated and ethanolic extract of pomegranate treated) and APP-CT (Aqueous extract of pomegranate pretreated and CCl 4 treated). Each sub group consisted of 6 rats. All rats received basal diet for 8 days. In addition to basal diet on 8 th day, BC received single dose olive oil and CC received CCl 4 . Rats of SC received silymarin for 8consecutive days . In experimental groups, CP-APT received aqueous extract of Pomegranate and CP-EPT received ethanolic extract of Pomegranate for 8consecutive days. Moreover, APP-CT received aqueous extract of Pomegranate for 8 consecutive days and CCl 4 only on 8 th day. All rats were sacrificed on 9 th day and then blood samples were collected. Serum ALT and AST levels were estimated by using standard laboratory kits. Statistical analysis was done one way ANOVA and Bonferroni test. Results: The mean serum AST and ALT levels were significantly (p<0.001) higher in CC in comparison to those of BC. Serum AST and ALT levels of all experimental groups were significantly (P<0.001) lower than CC. Silymarin used as a standard reference also exhibited significant hepatoprotective activity against CCl 4 induced hepatotoxicity Conclusion: From the result of present study it can be concluded that, Pomegranate may have hepatoprotective effect by lowering ALT and AST levels.
Background: Serum LDH level is an useful biomarker for cellular injury which may reflect the severity of preeclampsia and its level might be a guideline for the management of patient.Objective: To assess serum LDH level in preeclamptic women.Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College (DMC), Dhaka from January to December 2014. Total 105 pregnant women during third trimester (28-40 weeks) aged 18 to 35 years were selected from the Department of Obstetrics & Gynecology of DMC Hospital, Dhaka for this study. Among them, 35 were mild preeclamptic and 35 were severe preeclamptic women. Age matched 35 normotensive pregnant women were control. Serum LDH level was estimated by continuous spectrophotometric method.Results: In this study, serum LDH level was significantly higher (P<0.001) in preeclamptics compared to those of control. Again, this value was significantly higher in severe preeclamptics than those of mild preeclamptics. Moreover, 82.9% mild preeclamptic and 91.4% severe preeclamptic women had abnormally elevated serum LDH level (>200 U/L).Conclusion: From this study, it can be concluded that elevated serum LDH level is associated with severity of preeclampsia.Bangladesh Soc Physiol. 2015, December; 10(2): 71-75
Introduction: Pregnancy is a physiological process. Preeclampsia is the commonest complication during pregnancy. This condition might severely affect the health of mothers and their newborns. Newborn of mothers with preeclampsia are more liable for intrauterine growth retardation and may be delivered prematurely. Aim of the Study: The aim of this study was to evaluate the platelet count and mean platelet volume in newborn of preeclamptic mother. Methods: This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from January 2017 to December 2017. Total 60 newborns were included in this study. The subjects were divided into 2 groups. Group A (Study group): Thirty (30) newborns of preeclamptic mother and Group B (Control group): Thirty (30) newborns of healthy pregnant mother. The subjects were selected from Department of Obstetrics and Gynecology, Dhaka Medical College Hospital, Dhaka on the basis of exclusion and inclusion criteria. Five (5) ml. of cord blood was collected from each newborn after delivery and was analyzed for Platelet count and mean platelet volume. These parameters were estimated in the Department of Hematology, Dhaka Medical College Hospital, Dhaka. Data were collected in pre- designed structured questionnaire form by the researcher herself. For statistical analysis Unpaired Student’s “t” test, Chi Square test and Pearson’s correlation coefficient (r) test were performed as applicable using SPSS for windows version 16.0. p value <0.05 was accepted as level of significance. Results: The mean (± SD) platelet count was 164.77 ± 79.44 × 103/µl and 212.83 ± 54.04 ×103/µl in group A and B respectively. In this study, the mean (±SD) platelet count was lower in group A in comparison to that of group B which was statistically significant (p<0.001). The mean (± SD) platelet volume was 8.90±1.15 fl and 8.30±1.45 fl in group A and B respectively. In this study, the mean (±SD) platelet volume was higher in group A in comparison to that of group B which was not statistically significant. Maternal systolic blood pressure showed negative correlation (- 0.952) with platelet count of newborn in preeclamptic mother, which was statistically significant (p<0.001). Maternal diastolic blood pressure showed negative correlation (- 0.960) with platelet count of newborn in preeclamptic mother, which was statistically significant (p<0.001). Maternal systolic blood pressure showed negative correlation (-0.973) with mean platelet volume of newborn in preeclamptic mother, which was not statistically significant (p>0.05). Maternal diastolic blood pressure showed negative correlation (-0.964) with mean platelet volume of newborn in preeclamptic mother, which was not statistically significant (p>0.05). Conclusion: From the findings of the study, it can be concluded that the platelet count of newborn of preeclamptic mother was significantly lower in comparison to newborn of healthy pregnant mother but they were within normal range. This difference was significantly related to severity of maternal blood pressure. But there was no statistically significant difference in mean platelet volume between the groups. There was no statistically significant relation of mean platelet volume to maternal blood pressure.
2) late onset preeclampsia (after 34 wks gestation) 5 .Preeclampsia creates a functional derangement of multiple organ system. Complications of preeclampsia include eclampsia, placental abruption, ascities, hepatic infarction and rupture, intra-abdominal bleeding, pulmonary edema and acute renal failure. Twenty percent (20%) of women with severe preeclampsia develops HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) and the same percentage (20%) among HELLP syndrome develops disseminated intravascular coagulation (DIC). Complications affecting the developing fetus include intrauterine growth retardation, prematurity, oligohydramnios, bronchopulmonary dysplasia and increased risk of perinatal death 2 . During normal pregnancy profound changes occur in the coagulation and fibrinolytic system of the mother causing a hypercoagulable state. In preeclampsia there is a distinct possibility of accentuation of this hypercoagulable state of pregnancy 4 .Numerous studies observed coagulation abnormalities in preeclampsia. The level of anticoagulants such as antithrombin III, protein C and protein S are decreased in these groups. The clotting factors such as factor VIII and von Willebrand factors are elevated in preeclampsia. There is also increase in plasminogen activator inhibitor type 1(PAI-1) in preeclampsia. So preeclampsia is a highly thrombotic and procoagulant state 1 .Fibrinogen is the primary blood clotting factor. Fibrin clot is formed from fibrinogen. Fibrinogen plays a vital role in the process of inflammation, atherogenesis and thrombogenesis. Fibrinogen is a cofactor in platelet activation and may directly contribute to platelet plaque
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