Our findings indicated that pre-pregnancy obesity should be considered as an important risk factor for macrosomia. The effect of pre-pregnancy obesity on macrosomia need to be carefully assessed and monitored.
The multiple-breath washout (MBW) test allows for the measurement of lung volumes, ventilation homogeneity and gas clearance curves during tidal breathing [1]. Lung clearance index (LCI), the most commonly reported parameter from the MBW test, is a marker of ventilation inhomogeneity and is associated with early lung disease. LCI is defined as the cumulative expired volume divided by the functional residual capacity (FRC). The currently accepted reference equation for LCI measured using sulfur hexafluoride (SF
6
) shows a non-linear decrease as age and height increase, with height as an independent predictor from infancy to school-age [2]. In contrast, FRC shows a non-linear increase in FRC as age and height increase with males having higher measured FRC compared to female subjects.
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