Early life exposure to phthalates and the development of childhood asthma among Canadian children

Navaranjan, Garthika; Diamond, Miriam L.; Harris, Shelley A.; Jantunen, Liisa M.; Bernstein, Sarah N.; Scott, James A.; Takaro, Tim K.; Dai, Ruixue; Lefebvre, Diana L.; Azad, Meghan B.; Becker, Allan B.; Mandhane, Piush J.; Moraes, Theo J.; Simons, Elinor; Turvey, Stuart E.; Sears, Malcolm R.; Subbarao, Padmaja; Brook, Jeffrey R.

doi:10.1016/j.envres.2021.110981

Cited by 29 publications

(26 citation statements)

References 53 publications

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“…The CHILD Cohort Study is a prospective study that recruited 3455 pregnant mothers between 2008 to 2012 from health centers across Canada: Edmonton, Toronto, Manitoba (Winnipeg, Morden, and Winkler), and Vancouver. Details on recruitment and inclusion criteria for families in the CHILD Cohort Study as well as the inclusion/exclusion criteria for the case-cohort design used in this study have been published elsewhere. ,, Briefly, for our case-cohort study, from 2319 eligible CHILD study participants (described in S1; Figure S1), we randomly selected 436 children (random subcohort) (sample size based on the total number of cases, statistical power for analyses, and funds available to analyze house dust). This random subcohort included 30 children with asthma at 5 years and 61 children with recurrent wheeze between 2 and 5 years .…”

Section: Materials and Methodsmentioning

confidence: 99%

“…Details on recruitment and inclusion criteria for families in the CHILD Cohort Study as well as the inclusion/exclusion criteria for the case-cohort design used in this study have been published elsewhere. ,, Briefly, for our case-cohort study, from 2319 eligible CHILD study participants (described in S1; Figure S1), we randomly selected 436 children (random subcohort) (sample size based on the total number of cases, statistical power for analyses, and funds available to analyze house dust). This random subcohort included 30 children with asthma at 5 years and 61 children with recurrent wheeze between 2 and 5 years . This subcohort was enriched with other children in the eligible cohort (i.e., the 2319 participants) who were diagnosed with asthma at 5 years ( n = 99) and recurrent wheeze between 2 and 5 years ( n = 271) (which included most of the children with asthma at 5 years; n = 80) .…”

Section: Materials and Methodsmentioning

confidence: 99%

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Early Life Exposure to Tris(2-butoxyethyl) Phosphate (TBOEP) Is Related to the Development of Childhood Asthma

Navaranjan

Jantunen

Diamond

et al. 2021

Environ. Sci. Technol. Lett.

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We investigated the association between exposure to 29 organophosphate esters (OPEs) and the onset of childhood asthma and recurrent wheeze. Using a case-cohort design nested in the Canadian CHILD Cohort Study, we included a random sample of children (n = 429), all children with asthma at 5 years (n = 128), and all children with recurrent wheeze between 2 and 5 years (n = 331). The association between 14 highly detected OPEs measured in house dust vacuumed when children were 3−4 months of age, including the child's sleeping environment, and asthma at 5 years and recurrent wheeze between 2 and 5 years was assessed using logistic regression. The most abundant OPEs were TBOEP (median: 45730 ng/g) ≫ TCiPP (6065 ng/g) > TCEP (5260 ng/g) > TPhP (4440 ng/g) > EHDPP (1750 ng/g). Concentrations were higher than those in most other studies worldwide, potentially due to the inclusion of dust from the child's sleeping area. A 2−4-fold increased odds of asthma was observed across all quartiles of exposure to TBOEP compared to the lowest quartile, including a positive dose−response relationship. Inverse relationships (p < 0.05) were observed with the odds of asthma and recurrent wheeze for 24DiPPDPP, B4tBPPP, tri-m-cresyl phosphate (TmCP), and EHDPP, and between 4tBPDPP and odds of asthma.

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Section: Materials and Methodsmentioning

confidence: 99%

Section: Materials and Methodsmentioning

confidence: 99%

Early Life Exposure to Tris(2-butoxyethyl) Phosphate (TBOEP) Is Related to the Development of Childhood Asthma

Navaranjan

Jantunen

Diamond

et al. 2021

Environ. Sci. Technol. Lett.

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“…Maternal exposure starting before conception and continuing is associated with an approximately two‐fold increased risk of childhood asthma and/or wheeze 42 . This is particularly evident for phthalate exposure for which even low‐level exposure in early life was associated with up to a fourfold increase in the risk of asthma and recurrent wheeze at 5 years of age in a dose‐dependent manner 43 . Similarly, the use of PVC flooring or wall covering has been reported to be associated with the development of asthma among children and endocrine‐disrupting chemicals exposure in classrooms may not only impact obesity risk but also the pathogenesis of the obesity and asthma phenotype through a process mediated by the autonomic nervous system 44 .…”

Section: Environmental Pollutants As Determinants Of Childhood Asthmamentioning

confidence: 99%

Environmental inequality: Air pollution and asthma in children

Paciência

Rufo

Moreira

2022

Pediatric Allergy Immunology

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Dirty air is now recognized as the single biggest environmental threat to human health. 1 The air we breathe is becoming increasingly polluted and its impact on health is appraised to be as great as other major global health risks such as unhealthy diet, sedentarism, or tobacco. Nonetheless, air pollution is hard to escape. An emerging body of evidence emphasizes the associations between poorquality environments and socioeconomic conditions at both local and regional scales. 2 Whether you benefit from high-quality urban

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“…Many epidemiology studies have been conducted to explore the associations between environmental chemicals exposure and asthma, including phthalates, organophosphate insecticides, polyaromatic hydrocarbons (PAHs), paraben, and per-and poly uoroalkyl substances (PFASs) (Humblet et al 2014, Navaranjan et al 2021, Quirós-Alcalá et al 2019). However, scienti c evidence on pyrethroid exposure and the prevalence of asthma is relatively scarce (Mattila et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Association between environmental pyrethroid exposure and asthma among U.S. children and adults in National Health and Nutrition Examination Survey (2007–2014)

Guo

Wang

et al. 2022

Preprint

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Objectives: The evidence interpreting the association between environmental pyrethroid exposure and asthma is limited. The objective of this study was to examine the association between pyrethroid exposure and asthma among U.S. children and adults. Methods: Participants were collected from the National Health and Nutrition Examination Survey (NHANES, 2007-2014), including children and adults. 3-phenoxybenzoic acid (3-PBA) was used as a biomarker for pyrethroid metabolites. Multiple logistic regression models were constructed to estimate the association of urinary 3-PBA with asthma among children and adults and to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Additionally, a restricted cubic spline plot with three knots was applied to assess the potential nonlinear relationship between pyrethroid exposure and asthma.Results: Collectively, 7,776 participants were enrolled, including 2,236 children and 5,540 adults. The weighted prevalence of asthma in children and adults was 12.23% and 8.66% respectively. After adjusting for age, sex, race/ethnicity, poverty income ratio (PIR), body mass index (BMI), serum cotinine, urinary creatinine and family history of asthma, our results indicated that higher levels of 3-PBA was positively related to the risk of asthma among children (OR: 1.395; 95%CI: 0.880, 2.210) and adults (OR: 1.177; 95%CI: 0.778, 1.781). This positive association seemed to be more pronounced among 12-19-years old children and girls. Furthermore, the restricted cubic spline plot showed a linear relationship between levels of 3-PBA and asthma among children and adults (p for nonlinearity was 0.693 and 0.691 respectively).Conclusions: Our study observed a positive association between 3-PBA and asthma among children and adults while this positive association was more pronounced among children. However, we can not role out the possibility that the possible role of other co-occurring pesticides and other chemicals in the observed trends in asthma incidence. Therefore, further studies are needed to evaluate the possible pathogenic role of pyrethroid insecticides in asthma.

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Early life exposure to phthalates and the development of childhood asthma among Canadian children

Cited by 29 publications

References 53 publications

Early Life Exposure to Tris(2-butoxyethyl) Phosphate (TBOEP) Is Related to the Development of Childhood Asthma

Early Life Exposure to Tris(2-butoxyethyl) Phosphate (TBOEP) Is Related to the Development of Childhood Asthma

Environmental inequality: Air pollution and asthma in children

Association between environmental pyrethroid exposure and asthma among U.S. children and adults in National Health and Nutrition Examination Survey (2007–2014)

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