Herein, a multifunctional bilayer wound patch is developed by integrating a debonding-on-demand polymeric tissue adhesive (DDPTA) with an ionic conducting elastomer (ICE). As a skin adhesive layer, the DDPTA is soft and adherent at skin temperature but hard and non-tacky when cooled, so it provides unique temperature-triggered quick adhesion and non-forced detachment from the skin. During use, the dense surface of the DDPTA prevents blood infiltration and reduces unnecessary blood loss with gentle pressing. Moreover, its hydrophobic matrix helps to repel blood and prevents the formation of clots, thus precluding wound tearing during its removal. This unique feature enables the DDPTA to avoid the severe deficiencies of hydrophilic adhesives, providing a reliable solution for a wide range of secondary wound injuries. The DDPTA is versatile in that it can be covered with ICE to configure a DDPTA@ICE patch for initiating non-verbal communication systems by the fingers, leading toward sign language recognition and a remote clinical alarm system. This multifunctional wound patch with debonding-on-demand can promote a new style of tissue sealant for convenient clinical communication.
In this study, dual-ligand lanthanide metal−organic infinite coordination polymer (BDC-NH 2 -Tb-AMP ICPs) with dual fluorescence emission was constructed. Considering that quinolone antibiotics can sensitize Tb 3+ luminescence, the diverse fluorescence responses for different antibiotics on Tb 3+ at various pH's are distinct due to their structures. Inspired by these facts, a fluorescent sensor array, in which the pH-regulated BDC-NH 2 -Tb-AMP ICPs acted as the sensing element, was proposed for the pattern recognition of five representative quinolone antibiotics using principal component analysis. Furthermore, the sensor array can realize the detection of environmental quinolone antibiotics in real samples, confirming its reliability and practicality in complex conditions. More broadly, by using the simple yet powerful strategy of pH regulation, the presented sensor array holds a great ability for efficiently distinguishing quinolone antibiotics, which provides an approach for point-ofcare monitoring of residual antibiotics in the environmental field.
Microfluidic chips are in critical demand for emerging applications in material synthesis and biosensing. Herein, we relied on ultrafast laser-processing technology to fabricate a three-dimensional (3D) microfluidic chip, in which semiconducting polymer nanoparticles (SPNs) were continuously synthesized with tunable size and SPN-involved online fluorescence sensing was implemented. A homogeneous distribution of SPNs can be readily realized due to the efficient mixing and powerful vortices of the 3D microfluidic chip, which prevents SPNs from aggregating throughout the synthesis process. Moreover, in the optimized conditions, we unveiled unique SPNs with an ultrasmall particle size (<3 nm) and good monodispersity. By integrating with the high-performance fluorescence of SPNs and 3D microfluidic chip, we further developed an online sensing platform for ratiometric fluorescence assays of H 2 O 2 and oxidase-catalyzed substrates (e.g., glucose), in which a composite of SPNs and neutral red (NR) (SPNs/NR) was used as the mediator. The limit of detection (LOD) for H 2 O 2 is 0.48 μM, and the LOD for glucose is 3.33 μM via the presented platform. This 3D microfluidic synthesis-and-sensing platform provides a new avenue for the facile production of nanoparticles and offers exciting prospects in the field of online sensing biomarkers.
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