Wound healing greatly affects patients' health and produces medical burden. Therefore, we developed a multifunctional electrospun nanofiber dressing, which can inhibit methicillin-resistant Staphylococcus aureus (MRSA), drain excessive biofluid to promote wound healing, and simultaneously monitor wound pH level. The polyoxometalate (α-K 6 P 2 W 18 O 62 •14H 2 O, P 2 W 18 ) and oxacillin (OXA) are encapsulated in hydrophobic polylactide (PLA) nanofiber to synergistically inhibit MRSA. The phenol red (PSP) is encapsulated in hydrophilic polyacrylonitrile (PAN) nanofiber to sensitively indicate wound pH in situ. The PSP/PAN nanofiber is directly electrospun on the patterning OXA/P 2 W 18 /PLA nanofiber layer to form a Janus dressing. By taking advantage of the wettability difference between the two layers, the excess biofluid can be drained away from the wound. In addition, the Janus dressing exhibits good biocompatibility and accelerates wound healing via its antimicrobial activity and skin repairing function. This multifunctional Janus electrospun nanofiber dressing would be beneficial for wound management and treatment.
Oxidative stress is related to many
diseases, but available clinical
treatment methods are currently limited. Exploitation of enzyme-mimicking
nanomaterials (nanozymes) is a promising way for scavenging reactive
oxygen species (ROS) and treatment of ROS-related diseases. Herein,
the catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase
(GP
x
) mimicking activities are expressed
by MnO2 nanoparticles (MnO2
–BSA NPs) coated with BSA. Effective •OH removal
activity is also expressed by MnO2
–BSA
NPs at neutral pH. Apoptosis inhibition and ROS scavenging capabilities
of MnO2
–BSA NPs are evident on the H2O2-exposed BEAS-2B cells line. Western blot analysis
indicates that MnO2
–BSA NPs inhibit H2O2-induced apoptosis by mediating the expression
of apoptosis-related proteins.
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