Persistent inflammation caused by implant-associated
biofilm infections
has emerged as a significant clinical issue. While many methods have
been developed to give implants great anti-biofilm benefits, the post-inflammatory
microenvironment is frequently disregarded. Oxidative stress (OS)
due to excessive reactive oxygen species (ROS) is considered to be
one of the specific physiological signals of the inflammation microenvironment.
Herein, ZIF-90-Bi-CeO2 nanoparticles (NPs) were incorporated
into a Schiff-base chemically crosslinked hydrogel composed of aldehyde-based
hyaluronic acid and gelatin. Through chemical crosslinking between
polydopamine and gelatin, the hydrogel coating adhered to the Ti substrate.
The modified Ti substrate gained multimodal antibacterial and anti-biofilm
functions, which were attributed to the photothermal effect of Bi
NPs, and the release of Zn ions and CeO2 NPs. Notably,
CeO2 NPs endowed the system with dual-enzyme (SOD- and
CAT-like) catalytic activities. In a rat implant-associated infection
(IAI) model, the dual-functional hydrogel had a biofilm-removal ability
and regulated OS and inflammatory responses to facilitate osseointegration.
The photothermal therapy combined with a host inflammation-microenvironment
regulation strategy might provide a novel treatment for biofilm infection
and the accompanying excessive inflammation.
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