Here, a novel macroporous hydrogel dressing is presented that can accelerate wound healing and guard against bacteria-associated wound infection. Carboxymethyl agarose (CMA) is successfully prepared from agarose. The CMA molecular chains are cross-linked by hydrogen bonding to form a supramolecular hydrogel, and the hydroxy groups in the CMA molecules complex with Ag + to promote hydrogel formation. This hydrogel composite exhibits pH-responsiveness and temperature-responsiveness and releases Ag + , an antibacterial agent, over a prolonged period of time. Moreover, this hydrogel exhibits outstanding cytocompatibility and hemocompatibility. In vitro and in vivo investigations demonstrate that the hydrogel has enhanced antibacterial and anti-inflammatory capabilities and can significantly accelerate skin tissue regeneration and wound closure. Astonishingly, the hydrogel can cause the inflammation process to occur earlier and for a shorter amount of time than in a normal process. Given its excellent antibacterial, anti-inflammatory, and physicochemical properties, the broad application of this hydrogel in bacteriaassociated wound management is anticipated.
The biological carbon pump (BCP) stores ∼1,700 Pg C from the atmosphere in the ocean interior, but the magnitude and direction of future changes in carbon sequestration by the BCP are uncertain. We quantify global trends in export production, sinking organic carbon fluxes, and sequestered carbon in the latest Coupled Model Intercomparison Project Phase 6 (CMIP6) future projections, finding a consistent 19 to 48 Pg C increase in carbon sequestration over the 21st century for the SSP3-7.0 scenario, equivalent to 5 to 17% of the total increase of carbon in the ocean by 2100. This is in contrast to a global decrease in export production of –0.15 to –1.44 Pg C y
–1
. However, there is significant uncertainty in the modeled future fluxes of organic carbon to the deep ocean associated with a range of different processes resolved across models. We demonstrate that organic carbon fluxes at 1,000 m are a good predictor of long-term carbon sequestration and suggest this is an important metric of the BCP that should be prioritized in future model studies.
In this study, the crude exopolysaccharides (CEPSs) from fungus Aspergillus cristatus (MK346334, NCBI) isolated from Fuzhuan brick tea and its main purified fraction (EPSs-2) were prepared. With RAW264.7 cell model,...
In article number 2000644, Changhu Xue, Xiangzhao Mao, and co‐workers develop a macroporous hydrogel dressing with antibacterial and anti‐inflammatory properties for accelerated wound healing. The hydrogel matrix is formed by hydrogen bonding and supramolecular complexation. The hydrogel shows outstanding biocompatibility and can significantly accelerate skin tissue regeneration and wound closure.
A testing procedure has been developed to evaluate the effectiveness of cetane improvers for improving the ignition properties of diesel fuels. Among the factors considered in developing this procedure were the availability, characterization, and toxicity of the base fuel, the ease of measurement of the data, and the sensitivity of the analysis. This particular method has several advantages over previously used methods and is suitable for obtaining fundamental information on performance trends. Performance data are reported for 2-ethylhexyl nitrate (EHN) and tetraethylene glycol dinitrate (TEGDN). The data show that inconsistencies in reported performances for these cetane improvers can be explained by different apparent activation energies for the respective ignition processes as well as the lower solubility of TEGDN.
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