A Macroporous Hydrogel Dressing with Enhanced Antibacterial and Anti‐Inflammatory Capabilities for Accelerated Wound Healing

Huang, Wen‐Can; Ying, Rui; Wang, Wei; Guo, Yuna; He, Yongjun; Mo, Xinya; Xue, Changhu; Mao, Xiangzhao

doi:10.1002/adfm.202000644

Cited by 243 publications

(188 citation statements)

References 35 publications

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“…Supramolecular polymer hydrogels have attracted considerable attention in biomedical fields involving drug and cell delivery carriers, [1] wound dressings, [2] bioadhesives, [3] postoperative antiadhesion barriers, [4] and tissue engineering and From another perspective, we intentionally replaced methylene with NH group on the side of NAGA to form a new monomer N-acryloyl semicarbazide (NASC) with pendent one amide and one urea group. The resultant poly(N-acryloyl semicarbazide) (PNASC) hydrogels achieved ultrastiffness (up to 100.3 MPa of Young's moduli) in the swelling equilibrium state, which was much superior to that of both linear and hyperbranched PNAGA hydrogels due to stronger H-bonding interactions.…”

Section: Introductionmentioning

confidence: 99%

An Ultrasoft Self‐Fused Supramolecular Polymer Hydrogel for Completely Preventing Postoperative Tissue Adhesion

et al. 2021

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The supramolecular polymer hydrogels feature self-healability, adjustable mechanical strength, and thermoplasticity, which are derived from the formation of supramolecular physical interactions in the hydrogel networks, such as H-bonding interactions, [6] host-guest interactions, [7] metal-ligand coordination interactions, [8] hydrophobic interactions, [9] multiple combined interactions. [10] Among them, H-bonds are generally weak noncovalent bonds, ubiquitous in biomolecules, but their synergistic interactions can reach a strength of the covalent bond; thus it is commonly utilized in designing supramolecular tough hydrogels. [11] Our previous study suggested that supramolecular polymer hydrogels based on single amide H-bonding interaction were unstable in water, [12] because the competitive solvation of H-bond donor and acceptor in polar solvents weakens its strengthening effect. [13] Inspired by the hydrogen-bonded clusters in the secondary structure of proteins, we constructed a supramolecular poly(N-acryloyl glycinamide) (PNAGA) hydrogel whose dual amide motifs in the side chain contributed to high strengths and outstanding antiswelling ability due to strong shielding of the hydrogen-bonded microdomains from water molecule attack. [12] By utilizing Type II photoinitiated self-condensing vinyl polymerization of N-acryloyl glycinamide (NAGA), the resultant hyperbranched PNAGA hydrogels demonstrated superior mechanical performances to those of linear PNAGA counterparts owing to the higher cross-linking density of H-bonds. [14] In addition, the H-bonding interactions of dual amide motifs could also be modulated by copolymerizing other monomers, [15][16][17][18] thus achieving the versatile hydrogels with mechanical properties spanning from high strength to soft injectability, which show promising applications as 3D printed osteochondral regeneration scaffold, [16] artificial vitreous body, [17] and postoperative antiadhesion barrier. [18] Our recent study revealed that only introducing one methyl group to the double bond of NAGA could lead to a considerable decrease in mechanical strengths and an increase in room temperature autonomous self-healability of the poly(N-methacryloyl glycinamide) hydrogels (MNAGA), which was resulted from the perturbation of one methyl substitution to H-bonds. [19] The intermolecular H-bonding density heavily influences the gelation and rheological behavior of hydrogen-bonded supramolecular polymer hydrogels, thus offering a delicate pathway to tailor their physicochemical properties for meeting a specific biomedical application. Herein, one methylene spacer between two amides in the side chain of N-acryloyl glycinamide (NAGA) is introduced to generate a variant monomer, N-acryloyl alaninamide (NAAA). Polymerization of NAAA in aqueous solution affords an unprecedented ultrasoft and highly swollen supramolecular polymer hydrogel due to weakened H-bonds caused by an extra methylene spacer, which is verified by variabletemperature Fourier transform infrared (FTIR) spectroscopy and s...

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Section: Introductionmentioning

confidence: 99%

An Ultrasoft Self‐Fused Supramolecular Polymer Hydrogel for Completely Preventing Postoperative Tissue Adhesion

et al. 2021

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“…Fibroblasts play a critical role in normal wound healing 45 . Furthermore, the outer hydrogel of the IS can absorb and retain wound exudate, and promote the proliferation of fibroblasts and consequently the formation of wound epithelium 46 , 47 . Compared with the control and PD5 groups, the amount of deposited collagen in the IS group initially increased and then decreased.…”

Section: Resultsmentioning

confidence: 99%

3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer

et al. 2020

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Rationale: Tumors are commonly treated by resection, which usually leads to massive hemorrhage and tumor cell residues, thereby increasing the risk of local recurrence and distant metastasis. Methods: Herein, an intelligent 3D-printed poly(lactic-co-glycolic acid), gelatin, and chitosan scaffold loaded with anti-cancer drugs was prepared that showed hemostatic function and good pH sensitivity. Results: Following in situ implantation in wounds, the scaffolds absorbed hemorrhage and cell residues after surgery, and promoted wound healing. In an in vivo environment, the scaffold responded to the slightly acidic environment of the tumor to undergo sustained drug release to significantly inhibit the recurrence and growth of the tumor, and reduced drug toxicity, all without causing damage to healthy tissues and with good biocompatibility. Conclusions: The multifunctional intelligent scaffold represents an excellent treatment modality for breast cancer following resection, and provides great potential for efficient cancer therapy.

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“…E. coli and S. aureus were used to evaluate the antibacterial efficacy of all samples using the colony counting method. [41] Briefly, bacterial suspension (0.5 mL) was mixed with lysogeny broth (LB) liquid medium (7 mL) and then incubated for 18 h at 24 °C. Subsequently, the suspension was 100-fold diluted with LB liquid medium, followed by 100-fold dilution with phosphate buffered saline (PBS).…”

Section: Methodsmentioning

confidence: 99%

Designing Robust, Breathable, and Antibacterial Multifunctional Porous Membranes by a Nanofluids Templated Strategy

Hao

Yang

et al. 2020

Adv Funct Materials

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Advanced medical dressings need to meet these requirements of breathability, moisture absorption balance, antibacterial activity, and mechanical strength. Both breathability and moisture absorption balance strongly depend on the porous structure that inversely sacrifice their mechanical properties and bulk antibacterial activity. Herein, multifunctional porous structure is designed that can synchronously realize excellent antibacterial activity, breathability, superhydrophilicity, and enhanced mechanical properties just using nanofluids templating. The pore sizes, density, and functionality of porous polymers are regulated through nanofluids loading and multiple functional components including inorganic nanoparticles core and organic corona/canopy composed of organic long chains with different charges. An ionically tethered, nonylphenol polyoxyethylene ether sulfate as a canopy of nanofluids can be removed with sodium chloride solution to form porous structure, greatly improving the breathability of membrane and achieving superhydrophilicity to obtain moisture absorption balance. Meantime, exposed polysiloxane quaternary ammonium salts as covalently bonded corona of nanofluids exhibit excellent antibacterial activity. Finally, nanoparticles core endows supreme tensile strength ratio (115%) of porous membrane. Overall, nanofluids templating approach is expected to develop into a universal strategy to construct a series of multifunctional porous polymer materials via varying the component of nanofluids, which provide a promising application in biomedicine, human health, and life science.

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A Macroporous Hydrogel Dressing with Enhanced Antibacterial and Anti‐Inflammatory Capabilities for Accelerated Wound Healing

Cited by 243 publications

References 35 publications

An Ultrasoft Self‐Fused Supramolecular Polymer Hydrogel for Completely Preventing Postoperative Tissue Adhesion

An Ultrasoft Self‐Fused Supramolecular Polymer Hydrogel for Completely Preventing Postoperative Tissue Adhesion

3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer

Designing Robust, Breathable, and Antibacterial Multifunctional Porous Membranes by a Nanofluids Templated Strategy

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