P53 is a tumor suppressor gene that has been implicated in the pathogenesis of a wide range of tumor types including colorectal cancers. bcl2 is a proto-oncogene that inhibits apoptosis. Immunostaining for P53 and BLC2 protein product was performed in a retrospective series of 80 colorectal carcinomas with a minimum follow-up of 5 years. The aim of the study was to evaluate the prognostic significance of P53 and BCL2 protein expression and their correlation with clinicopathologic variables such as pathologic disease stage (Dukes system), histologic grade, and vascular invasion. The patients were 41 to 76 years of age, and the follow-up ranged between 5 and 10 years. Among the 80 cases, 30 were Dukes stage A and 50 stage B. We found vascular invasion in 21.2%. P53 and BCL2 expression was detected, respectively, in 30.0% and 8.8%. We concluded that the P53 and BCL2 expression detected by immunohistochemistry in routinely processed, paraffin-embedded tissues: (1) has no prognostic significance; and (2) was not correlated with pathologic disease stage, histologic grade, or vascular invasion. Nevertheless, the number of patients in our study was small, and we believe that investigation of a larger series of patients is indicated.
This article addresses the problem of the multiscale importance of road networks, with the aim of helping to establish a more resilient network in the event of a road disruption scenario. A new model for identifying the most important roads is described and applied on a local and regional scale. The work presented here represents a step forward, since it focuses on the interaction between identifying the most important roads in a network that connect people and health services, the specificity of the natural hazards that threaten the normal functioning of the network, and an assessment of the consequences of three real-world interruptions from a multiscale perspective. The case studies concern three different past events: road interruptions due to a flood, a forest fire, and a mass movement. On the basis of the results obtained, it is possible to establish the roads for which risk management should be a priority. The multiscale perspective shows that in a road interruption the regional system may have the capacity to reorganize itself, although the interruption may have consequences for local dynamics. Coordination between local and regional scales is therefore important. The model proposed here allows for the scaling of emergency response facilities and human and physical resources. It represents an innovative approach to defining priorities, not only in the prevention phase but also in terms of the response to natural disasters, such as awareness of the consequences of road disruption for the rescue services sent out to local communities.
Es objeto de este artículo analizar el efecto de la COVID-19 en la práctica deportiva de personas participantes en eventos deportivos de carrera a pie y ciclismo en España y Portugal. Se consideró la situación de práctica deportiva en España y Portugal previa a la irrupción de la COVID-19, como ambos Gobiernos legislan para proteger a los ciudadanos de la pandemia y se analizan las consecuencias de éstas. Se realizó una investigación descriptiva mediante el uso de cuestionario (N=2696) y análisis estadístico descriptivo según características y distribución (prueba de la normalidad) de las diferentes variables: frecuencias, valores medios, máximas y mínimas, mediana e IQR. De los resultados obtenidos se puede destacar: a) la casi plena coincidencia entre estados del perfil genérico de los practicantes; el orden por porcentaje de las variables, e incluso, los porcentajes de cada variable para cuatro de las cinco dimensiones analizadas; b) la dimensión que más difiere fue como se adaptaron durante la fase de confinamiento las personas practicantes en España y Portugal, y c) que en todo momento las personas encuestadas percibieron que las adaptaciones serían pasajeras y era cuestión de algunos meses que se volviera a la normalidad. Estos datos permiten entender el efecto que la pandemia de la COVID-19 tuvo en la práctica deportiva y de participantes de eventos deportivos en el medio natural en España y Portugal. Abstract. The aim of this article is to analyze the impact of COVID-19 on physical activity on people who participate on running and cycling sporting events people in Spain and Portugal. It was considered The situation of sports practice in Spain and Portugal prior to the outbreak of COVID-19, as both governments legislate to protect citizens from the pandemic and it was analyzed the consequences of these acts. A descriptive investigation was carried out using a questionnaire (N=2696) and descriptive statistical analysis according to characteristics and distribution (test of normality) of different variables: frequencies, average, maximum and minimum values, median and IQR. From the results, the following can be highlighted: a) almost complete coincidence between both countries, of the generic profile of the practitioners; the order, by percentage, of the variables, and even the percentages of each variable for four of the five dimensions analyzed; b) the dimension that differs the most is how practitioners in Spain and Portugal adapted during the confinement time, and c) at all times the respondents perceived that the adaptations would be temporary and it was a matter of a few months before they returned to the normality. These data allow to understand the effect of COVID-19 pandemic had on physical activity on people who participate on sporting events in the natural environment in Spain and Portugal.
A navegação consulta e descarregamento dos títulos inseridos nas Bibliotecas Digitais UC Digitalis, UC Pombalina e UC Impactum, pressupõem a aceitação plena e sem reservas dos Termos e Condições de Uso destas Bibliotecas Digitais, disponíveis em https://digitalis.uc.pt/pt-pt/termos.Conforme exposto nos referidos Termos e Condições de Uso, o descarregamento de títulos de acesso restrito requer uma licença válida de autorização devendo o utilizador aceder ao(s) documento(s) a partir de um endereço de IP da instituição detentora da supramencionada licença.Ao utilizador é apenas permitido o descarregamento para uso pessoal, pelo que o emprego do(s) título(s) descarregado(s) para outro fim, designadamente comercial, carece de autorização do respetivo autor ou editor da obra. Na medida em que todas as obras da UC Digitalis se encontram protegidas pelo Código do Direito de Autor e Direitos Conexos e demais legislação aplicável, toda a cópia, parcial ou total, deste documento, nos casos em que é legalmente admitida, deverá conter ou fazer-se acompanhar por este aviso.
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Este artigo aborda o percurso histórico e a evolução da implementação do cadastro territorial urbano no Brasil. Parte-se do pressuposto de que a sua evolução está diretamente ligada à dinâmica do processo de municipalização e de ocupação territorial do país, ampliado a partir da Constituição de 1946. O Projeto CIATA, nas décadas de 1970/80, é apresentado como a primeira iniciativa que formula uma metodologia nacional e conduz a implementação de cadastros urbanos. Registram-se, ainda, outras iniciativas governamentais de apoio financeiro à implementação de cadastros urbanos, bem como o cenário que se conforma a partir da Constituição de 1988, do Estatuto da Cidade e da criação do Ministério das Cidades, que publica, em 2009, as diretrizes para a elaboração do cadastro territorial urbano, sob a perspectiva multifinalitária. Palavras-chave: Cadastro Territorial Mulfinalitário, Cadastro Urbano, CIATA, Diretrizes para o CTM.
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