Triclosan (TCS) is used as an antimicrobial agent and has been widely dispersed and
detected in the aquatic environment. However, it remains uncertain whether TCS is
genotoxic or not. In this study, the acute toxicity of TCS in goldfish (
Carassius
auratus
) was studied. Then, based on the results for acute toxicity, other
goldfish were exposed to various concentrations of TCS (control, DMSO control, and 1/4,
1/2, and 1/8 LC
50
) for 14 days, and the effects on genetic toxicity were
evaluated using micronucleus (MN) and nuclear abnormalities (NA) frequencies in peripheral
blood and the comet assay in the liver of the goldfish. In addition, malondialdehyde
(MDA), reduced glutathione (GSH), catalase (CAT), and total antioxidant capacity (T-AOC)
in the liver were assayed to evaluate oxidative stress and the possible mechanism of
genotoxicity. The 96 h median lethal concentration of TCS was 1111.9
µ
g/l. After 14 days of exposure, the MN and NA frequencies were
significantly increased in peripheral blood of the TCS-treated groups compared with the
solvent control, and the comet tail moment and MDA in the liver in the highest dose of TCS
groups were also significantly high. Meanwhile, an evident change in GSH, CAT, and T-AOC
of the liver was found as the TCS exposure concentration increased. The results showed
that TCS caused oxidative stress and a genotoxic response in goldfish, suggesting that it
presents a potential ecotoxicological risk to aquatic ecosystems.
The present study investigated the impact of standardized perioperative nursing management on improving outcomes in patients with peptic ulcer disease. A total of 90 patients with peptic ulcers were admitted to the Wuhan Wuchang Hospital between July 2020 to July 2022. These patients were included in the present study. They were divided into 2 groups based on the nursing management that they received, with 45 patients classified into each group. The control group received routine nursing care, while the observation group received standardized perioperative nursing management. The improvement in clinical symptoms, recurrence rate, negative emotions and disease management capacity were compared between the 2 groups. The results demonstrated that the improvement rate of clinical symptom in the observation group was significantly higher as compared with the control group (P < .05). The recurrence rate in the observation group was significantly lower than in the control group (P = .026). Patients in the observation group had better psychological status, and better disease management capacity as compared with those in the control group (P < .05). The application of standardized perioperative nursing management for patients with peptic ulcer can help improve the patients' clinical symptoms, enhance their disease management capacity, reduce anxiety, and ensure the quality of nursing care.
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