PRIMARY MALIGNANT MELANOMA occurs most frequently in the skin and adjoining mucous membranes, next most frequently in the eye and least frequently in the meninges. Primary occurrence elsewhere is very doubtful, and in any case is conceded to be extremely rare. Malignant melanoma constitutes approximately 5 per cent of all malignant lesions of the skin.6 In ihe skin of the lower extremities, however, more than 50 per cent of all malignant tumors are melanomas.3' 9 Because of this relative
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