Histopathological Diagnosis of Malignant Melanoma

Couperus, Molleurus; Rucker, Rufus C.

doi:10.1001/archderm.1954.01540200059005

Cited by 38 publications

(8 citation statements)

References 10 publications

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“…The significance of the presence of inflammatory cells in naevi of the skin has been critically reviewed by Couperus and Rucker (1954) who concluded that an inflammatory infiltrate associated with a junctional naevus, not explained on some other basis, is indicative of malignant change until proved otherwise.…”

Section: Discussion Of Histological Resultsmentioning

confidence: 99%

Naevi and Melanomata of the Conjunctiva

Jay¹

1965

British Journal of Ophthalmology

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NAEvi are the most common benign tumours of the conjunctiva, and their malignant counterparts, the malignant melanomata, although far less frequently encountered, are among the most serious of the ocular neoplasms. In typical cases the histological diagnosis of naevi and melanomata is not difficult, but many cases are not typical, and it is these atypical cases that tax the diagnostic ability of the histopathologist, particularly if the lesion shows changes suggestive of malignancy. In addition to the diagnostic problems presented by these tumours their treatment is in dispute, mainly because, with certain notable exceptions, few clinicians have treated more than a smnall number of these tumours during their lifetime.The large collection of these tumours in the Department of Pathology at the Institute of Ophthalmology, London, presented an opportunity for clarifying certain aspects of melanotic lesions of the conjunctiva, and to this end all the naevi and malignant melanomata referred to the Department of Pathology between 1948 and 1961 were re-examined and their histological diagnoses either confirmed or adjusted. In addition, all those cases where a diagnosis of malignant, pre-malignant, or possibly malignant melanoma was made were followed up, by reference to the hospital notes if the patient had attended Moorfields Eye Hospital, and by writing to the referring surgeon or pathologist if the patient had attended another hospital.The purpose of this study is threefold. First, to classify naevi and malignant melanomata of the conjunctiva both with regard to accepted nomenclature and as a result of examining 400 such neoplasms histologically. Second, to ascertain the degree of malignancy of those tumours that are frankly malignant and of those that show changes suggestive of malignancy. Third, to compare the histological appearances of naevi and malignant melanomata of the conjunctiva with those of the skin.Review of the Literature From the earliest days of history man has been fascinated by birthmarks and their significance, giving explanations for their occurrence that in retrospect seem naive, bizarre, or frankly horrific. It is only in the last 150 years that a scientific approach *

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Section: Discussion Of Histological Resultsmentioning

confidence: 99%

Naevi and Melanomata of the Conjunctiva

Jay¹

1965

British Journal of Ophthalmology

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“…[1][2][3][4][5] When the naevic component is sizeable, distinction from the overlying ⁄ adjacent melanoma is relatively straightforward. However, when the naevic component (banal melanocytic aggregate) is small, the differentiation can be a diagnostic challenge.…”

Section: Discussionmentioning

confidence: 99%

RASandRAFmutations in banal melanocytic aggregates contiguous with primary cutaneous melanoma: clues to melanomagenesis

Dadzie

Yang

Emley

et al. 2009

British Journal of Dermatology

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“…de novo melanoma is thought to be more frequent than NAM, however, the exact prevalence of NAM has not been established, with. Indeed, prevalence ranging from 4–85% . Recent reviews and metanalysis highlighted a rate of 29.1–36% .…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, prevalence ranging from 4-85%. [3][4][5] Recent reviews and metanalysis highlighted a rate of 29.1-36%. 2,6 The exact biologic significance of NAM, their clinical and dermoscopic peculiarities compared to de nono melanoma, as well as its prognosis are still to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous melanoma associated with naevi prevalence: A 15‐year cross‐sectional retrospective study

et al. 2019

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Background/Objectives Melanoma may develop de novo or naevus associated (NAM). The exact prevalence and features of NAM are not fully elucidated. Methods A 15‐year cross‐sectional retrospective study was performed of all melanoma cases diagnosed and treated at the skin cancer centre of the University of Naples Federico II from September 2003 to August 2018. Data collected included patient's age, gender, melanoma anatomic site, Breslow thickness, and histolopathology including melanoma‐associated lesion characteristics. Results A total of 1986 melanomas were included in the study. Based on histolopathogical examination, NAM represented 8.4% (n = 167) with de novo melanoma representing the great majority of the melanomas (91.6%). NAM was significantly more common in younger age compared to de novo melamoma (mean age 48 ± 14.9 vs 54.3 ± 15.9 years, P < 0.001), and more frequently involved the trunk (62.3% vs 51.8% P = 0.01). Mean Breslow thickness was significantly higher in de novo melanoma compared to NAM (0.97 ± 1.48 mm vs 0.83 ± 0.95, P < 0.001). However, in situ melanoma was more commonly observed in de novo melanoma (n = 640, 35.2%) rather than NAM (n = 41, 24.5%; P < 0.01) whereas invasive melanoma represented 75.5% (n = 126) of NAM and 64.8% (n = 1179) of de novo melanoma, P < 0.01. Conclusions NAM represent a small percentage of melanomas (8.4%) compared to de novo melanoma. NAM appeared to be significantly more common in younger age and more frequently involved the trunk, being associated with an overall better prognosis, due to a lower mean Breslow thickness respect to de novo melanoma.

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Histopathological Diagnosis of Malignant Melanoma

Cited by 38 publications

References 10 publications

Naevi and Melanomata of the Conjunctiva

Naevi and Melanomata of the Conjunctiva

RASandRAFmutations in banal melanocytic aggregates contiguous with primary cutaneous melanoma: clues to melanomagenesis

Cutaneous melanoma associated with naevi prevalence: A 15‐year cross‐sectional retrospective study

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