The selective accumulation of S-ketoprofen and its acyl glucuronide are consistent with amplification of chiral inversion subsequent to futile cycling between R-ketoprofen and R-ketoprofen glucuronide. Severe renal insufficiency, and possibly more modest decrements, results in a disproportionate increase in systemic exposure to the S-enantiomer which inhibits both pathologic and homeostatic prostaglandin synthesis.
The aim of this study was to analyze the level of income, knowledge, and impact of climate change on fishing household. This research was conducted in Pekon Tegineneng, Limau Subdistrict, Tanggamus Regency. Limau Subdistrict is the center of marine capture fishery in Tanggamus Regency. Data collection was carried out from July to August 2020 with total respondent reached 80 fishing households. Respondents were determined through the approach of simple random sampling. The data collected consisted of both qualitative and quantitative data. Data collection was performed through the method of survey, Focus Group Discussion (FGD), and interview with key informants. Data were analyzed by the qualitative descriptive approach. The level of monthly income and expenditure per fishing household amounted to Rp. 4,110,000 and Rp. 3,971,200, respectively. Knowledge level of fisherman about climate change was considered excellent as most fishermen have already known the phenomena of climate and environmental changes. The impact of climate change on fishing household included: difficulty to predict fishing season, change in fishing location (away from the shore), reducing and unpredictable fishing frequency and fishing time, also declining of fish catch.
Penelitian ini bertujuan untuk mengetahui analisis pengaruh profitabilitas, leverage, dan ukuran perusahaan terhadap income smoothing. Data sekunder yang dikumpulkan dari perusahaan-perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia pada tahun 2013-2018. Metode yang digunakan adalah metode deskriptif kuantitatif. Sampel ditentukan berdasarkan metode purposive sampling, sebanyak 36 laporan keuangan. Teknis analisis data menggunakan regresi logistik yang diolah menggunakan bantuan progam SPSS versi 25. Hasil yang diperoleh dari penelitian ini menjelaskan bahwa terdapat 13 laporankeuangan perusahaan pertambangan dari 36 sampel melakukan income smoothing. Profitabilitas dan Ukuran Perusahaan tidak berpengaruh secara signifikan terhadap income smoothing dan Leverage berpengaruh secara signifikan terhadap income smoothing.
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