Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people and deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further establish the credentials of 'brainpredicted age' as a biomarker of individual differences in the brain ageing process, using a predictive modelling approach based on deep learning, and specifically convolutional neural networks (CNN), and applied to both pre-processed and raw T1-weighted MRI data.Firstly, we aimed to demonstrate the accuracy of CNN brain-predicted age using a large dataset of healthy adults (N = 2001). Next, we sought to establish the heritability of brainpredicted age using a sample of monozygotic and dizygotic female twins (N = 62). Thirdly, we examined the test-retest and multi-centre reliability of brain-predicted age using two samples (within-scanner N = 20; between-scanner N = 11). CNN brain-predicted ages were generated and compared to a Gaussian Process Regression (GPR) approach, on all datasets. Input data were grey matter (GM) or white matter (WM) volumetric maps generated by Statistical Parametric Mapping (SPM) or raw data. CNN accurately predicted chronological age using GM (correlation between brain-predicted age and chronological age r = 0.96, mean absolute error [MAE] = 4.16 years) and raw (r = 0.94, MAE = 4.65 years) data. This was comparable to GPR brain-predicted age using GM data (r = 0.95, MAE = 4.66 years). Brain-predicted age was a significantly heritable phenotype for all models and input data (h 2 = 0.50-0.84). Brain-predicted age showed high test-retest reliability (intraclass correlation coefficient [ICC] = 0.90-0.98). Multi-centre reliability was more variable within high ICCs for GM (0.83-0.96) and poor-moderate levels for WM and raw data (0.51-0.77).2 Brain-predicted age represents an accurate, highly reliable and genetically-valid phenotype, that has potential to be used as a biomarker of brain ageing. Moreover, age predictions can be accurately generated on raw T1-MRI data, substantially reducing computation time for novel data, bringing the process closer to giving real-time information on brain health in clinical settings.

Abstract. In cardiac magnetic resonance imaging, fully-automatic segmentation of the heart enables precise structural and functional measurements to be taken, e.g. from short-axis MR images of the left-ventricle. In this work we propose a recurrent fully-convolutional network (RFCN) that learns image representations from the full stack of 2D slices and has the ability to leverage inter-slice spatial dependences through internal memory units. RFCN combines anatomical detection and segmentation into a single architecture that is trained end-to-end thus significantly reducing computational time, simplifying the segmentation pipeline, and potentially enabling real-time applications. We report on an investigation of RFCN using two datasets, including the publicly available MICCAI 2009 Challenge dataset. Comparisons have been carried out between fully convolutional networks and deep restricted Boltzmann machines, including a recurrent version that leverages inter-slice spatial correlation. Our studies suggest that RFCN produces state-of-the-art results and can substantially improve the delineation of contours near the apex of the heart.

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We present NavACL, a method of automatic curriculum learning tailored to the navigation task. NavACL is simple to train and efficiently selects relevant tasks using geometric features. In our experiments, deep reinforcement learning agents trained using NavACL in collision-free environments significantly outperform state-of-the-art agents trained with uniform sampling -the current standard. Furthermore, our agents are able to navigate through unknown cluttered indoor environments to semantically-specified targets using only RGB images. Collision avoidance policies and frozen feature networks support transfer to unseen real-world environments, without any modification or retraining requirements. We evaluate our policies in simulation, and in the real world on a ground robot and a quadrotor drone. Videos of real-world results are available in the supplementary material. 1

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