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Introduction: Urinary tract infection (UTI) is one of the most common infections worldwide and the pattern of antimicrobial susceptibility varies widely in different geographical regions depending on the antibiotic policies. Aim: To know the bacteriological profile of UTIs and the antibiogram of uropathogens in eastern Uttar Pradesh. Material and Methods: This study was prospective and conducted at tertiary care center in one year study duration (2015). All the patients clinically suspected of having UTI were enrolled, culture and sensitivity was performed as per standard protocol, irrespective of age, sex, indoor/outdoor and associated illnesses. Results: In a total of 2217 patients, 967 (43.61 %) were positive for uropathogen by culture, and positivity in female was high (46.48%) as compared to male (38.46%). Escherichia coli was the most common 346 (35.80 %) uropathogen followed by Klebsiella pneumoniae 183 (18.92%) and Enterococcus species 125 (12.92%). Gram negative isolates were most sensitive to imipenem (92%), ceftazidime-clavulanic acid (71%), piperacillin-tazobactam (68%), amikacin (60%), followed by nitrofurantoin (56%). Gram positive isolates were most sensitive to vancomycin (91%) followed by linezolid (80%) and amoxycillin-clavulanic acid (45 %). Conclusion: UTI is a very common problem and rate of antibiotic resistance is relatively high. Imipenem, ceftazidimeclavulanic acid, piperacillin-tazobactam, amikacin, vancomycin and linezolid, were found sensitive against isolated uropathogens.

There is a need to identify the factors responsible for this low rate of subsequent publication, and interventions to improve it both at institutional and researchers' level.

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