There are several issues that need to be better understood before breast tissueengineering becomes viable clinically. One of the key issues is the interaction between cells and the microtopography of the implant surface. The aim of this study was to evaluate the efficacy of D1 cells, multipotent mouse bone marrow stromal precursors, in differentiating to fat and to characterize their metabolic activity (lactic acid released and glucose consumed) and lipid production when cultured on patterned poly-L-lactide (PLLA) films. It was determined that, with appropriate stimulation, the D1 cells displayed morphological characteristics of adipocytes and produced lipid. The results show that the patterned surfaces did affect the rate of lipid production. Polynomial models were proposed to predict the metabolic activity of the cells over a period of time. '
Originating from the authors' own graduate course at the University of North Carolina, this material has been thoroughly tried and tested over many years, making the book perfect for a two-term course or for self-study. It provides a concise introduction that covers all of the measure theory and probability most useful for statisticians, including Lebesgue integration, limit theorems in probability, martingales, and some theory of stochastic processes. Readers can test their understanding of the material through the 300 exercises provided. The book is especially useful for graduate students in statistics and related fields of application (biostatistics, econometrics, finance, meteorology, machine learning, and so on) who want to shore up their mathematical foundation. The authors establish common ground for students of varied interests which will serve as a firm 'take-off point' for them as they specialize in areas that exploit mathematical machinery.
Coach developers (CDs) are an integral aspect of the coaching education system in Canada, as they are responsible for the delivery of the National Coaching Certification Program (NCCP) to coaches. A means of understanding the role of CDs within the Canadian coaching education system is to gain insight into the enablers and challenges of the interorganizational relationships (IORs) between the stakeholders (e.g., organizations, CDs, and coaches). The purpose of this insights paper was to use IORs to understand the CD relationship with other stakeholders in the coach education system as they pertain to enablers and challenges. The use of IORs is a relatively new theoretical concept within the field of coaching and coach education as it pertains to CDs. Through the empirical evidence of three sports—hockey, soccer, and baseball—there were three key themes that were indicative of IORs: the NCCP delivery, communications, and monitoring/evaluating for effectiveness. On the basis of the findings from this current study, the intended system design of the Canadian coaching education system, which is based on role-set IOR, is a vertical model of top-down governance model. On the basis of the findings from this current study, the intended system design of the Canadian coaching education system, which is based on role-set IOR, is a vertical model of top-down governance, where one decision from the top impacts all the other stakeholders within the system.
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