In patients at average risk for colorectal cancer, CT colonography is a sensitive and specific screening test for detecting polyps 10 mm or larger; the sensitivity for detecting smaller polyps is decreased. Examination findings can be interpreted in a clinically feasible amount of time.

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Warfarin use did not decrease the positive predictive value of FOBT. These findings suggest that warfarin should not be discontinued prior to FOBT.

Low-dose CT colonography can detect highly significant extracolonic findings. Although extracolonic lesions were common, only a small proportion of patients required further diagnostic testing. Additional studies to determine the optimal radiation dose, cost-effectiveness, and legal implications of detecting extracolonic findings are warranted.

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Background: Testing stool for occult blood at the time of digital rectal examination (DRE) has been discouraged because it is thought to increase the number of falsepositive test results.

We theorize that the stiffness of the colon in areas of collagenous colitis with submucosal fibrosis makes it susceptible to linear "fractures" during colonoscopic air insufflation with subsequent transmural air dissection. We urge extreme caution if this lesion is recognized at colonoscopy and recommend aborting the examination and obtaining plain radiographs to detect free intraperitoneal air.