The occurrence of CMV disease at 12 months was similar between the groups (3.5% vs 3.4%; P=1.000). Log-rank test found no statistically significant difference in the time to development of CMV between the 2 groups (P=.939).

Drug-induced liver disease accounts for about 50% of acute or subacute liver failure in the United States. United Network of Organ Sharing (UNOS) data suggest 8%-20% of liver transplantation in this country per year is for fulminant liver failure due to drugs. Even though the most common medication implicated in acute liver injury is acetaminophen (75%), there are numerous other drugs that are responsible for acute and chronic liver injury. A variety of antifungal medications are known to cause a wide range of liver injury from a mild hepatocellular-cholestatic injury pattern to acute/subacute liver failure. Terbinafine is one of the antifungals that have been associated with such liver injuries. We report a case of terbinafine-induced severe liver failure requiring liver transplantation. Liver Transpl 13: 162-164, 2007.

The importance of human factors (ergonomics/ environment, task design, changing work patterns, organiza tional factors etc.) in the introduction and use of new informa tion technology is discussed, both from the general point of view of 'office work', and more specifically as it relates to library/information work. Considerations in the planning for, and introduction of, IT are outlined, and their significance for the role of the information scientist emphasized. (23 refer ences).