The use of heterogeneous bimetallic Pd-based nanocatalyst for directing the inactivated sp 3 CÀH coupling has been scarcely explored. This work reported the formation of symmetrical CÀC bonds from the inactivated sp 3 CÀH bonds catalyzed by employing reduced graphene oxide supported PtPd@Pt porous nanospheres. The reaction of sp 3 CÀH activation proceeded under mild conditions without any solvent, ligand or directing group. It is a higher atom-, step-and cost-effectiveness strategy for developing heterogeneous catalysts in the synthesis of bibenzyls with various functional groups (e. g. aryl, alkyl, methoxyl, halogen, ester, and pyridyl).
A heterogeneous Pd-Cu NWs-catalyzed expeditious and solvent-free synthesis of propargylamines via A 3 -coupling of aldehydes, alkynes, and amines has been proposed. A wide range of aldehydes, alkynes and amine substrates undergo A 3 -coupling to produce propargylamines in good to excellent yields with good functional tolerance, such as that towards alkoxy, hydroxy, C-X (X = F, Cl, Br) as well as amide and C=C bonds. Furthermore, the catalyst could be recovered easily and reused for at least 5 cycles without showing significant loss of catalytic activity.
A novel 5-exo-dig/6-endo-trig bicyclization of 1,6-enynes with sulfonyl hydrazides in aqueous phase using cheap and available tetrabutylammonium iodide (TBAI)-tert-butyl hydroperoxide (TBHP) combined system is reported. The resulting reaction of diverse...
A fast condensation of indene with a wide range of aldehydes catalyzed by cesium hydroxide monohydrate (CsOH·H2O) for the synthesis of benzofulvenes with good to excellent yields was demonstrated. The condensation can be completed within a few minutes under room temperature and air atmosphere without the use of special ligands or phase‐transfer catalysts. In addition, the ratio of indene to aldehydes played an important role in this reaction. The single condensation products 3 can be obtained as main products with a ratio of 1.2:1, whereas the double condensation products 4 can be obtained by changing the ratio to 1:2.2. This protocol provides an efficient, simple and general method for the synthesis of benzofulvenes 3 and double condensation products 4, which are important intermediates in the synthesis of numerous drugs and natural products.
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