Abstract-A novel practical low-complexity multicell orthogonal frequency-division multiple access (OFDMA) downlink channel-assignment method that uses a graphic framework is proposed in this paper. Our solution consists of two phases: 1) a coarse-scale intercell interference (ICI) management scheme and 2) a fine-scale channel-aware resource-allocation scheme. In the first phase, state-of-the-art ICI management techniques such as ICI coordination (ICIC) and base-station cooperation (BSC) are incorporated in our framework. In particular, the ICI information is acquired through inference from the diversity set of mobile stations and is presented by an interference graph. Then, ICIC or BSC is mapped to the MAX k-CUT problem in graph theory and is solved in the first phase. In the second phase, channel assignment is accomplished by taking instantaneous channel conditions into account. Heuristic algorithms are proposed to efficiently solve both phases of the problem. Extensive simulation is conducted for various practical scenarios to demonstrate the superior performance of the proposed solution compared with the conventional OFDMA allocation scheme. The proposed scheme can be used in next-generation cellular systems such as the 3GPP Long-Term Evolution and IEEE 802.16m.

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Background: PCR-based assays can improve clinical care, but they remain technically demanding and labor-intensive. We describe a new instrument, the GeneXpert ® , that performs automated nucleic acid isolation, reverse transcription, and fluorescence-based quantitative PCR in ϳ35 min. Methods: Yield and integrity of RNA isolated on the GeneXpert were compared with Qiagen-based extraction for parallel samples (5-m frozen tissue sections). The reproducibility of automated RNA isolation, reverse transcription, and quantitative PCR was determined by replicate (n ‫؍‬ 10) analysis of 10 tissues, using duplex (target and endogenous control) reverse transcription-PCR reactions for two gene combinations. The GeneXpert was then used to perform rapid analysis of lymph nodes from melanoma, breast cancer, and lung cancer patients and analysis of melanoma metastatic to the lung, primary lung adenocarcinoma, and healthy lung tissue. Results: On the GeneXpert, RNA was recovered in slightly over 6 min, and the yield was ϳ70% of that from parallel Qiagen reactions. The RNA integrity was comparable to that of Qiagen-isolated RNA as determined by gel electrophoresis. For the melanoma samples, the 95% prediction interval for the ⌬Ct for a new measurement was ؎1.54 cycles, and for breast cancer samples, the interval for a newly observed ⌬Ct was ؎1.40 cycles.

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A modulation scheme that maps the information onto the antenna indices, such as space shift keying (SSK) and its generalized form (namely, generalized SSK or GSSK), presents an attractive option for the emerging large-scale MIMO system due to the reduced algorithm and hardware cost. In this letter, we present a new modulation scheme in this category, where we propose use of the Hamming code construction technique to systematically design the constellation. An illustrative example and experimental studies demonstrate that the proposed scheme introduces rich design flexibility and achieves better transmission rate, performance, and power tradeoffs with comparable hardware costs as compared with existing schemes.

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