Pegfilgrastim 200 microg/kg, in excess of the 100 microg/kg dose used in limited pediatric clinical trials, appeared to exceed saturable neutrophil receptor-mediated clearance. The inability of this mechanism to self-regulate neutrophil counts in the normal range led to neutrophil overshoot. Routine pediatric use of the pegylated dosage form of G-CSF should await further published clinical trials to validate a safe and effective dose.
A 13-year-old boy with recurrent ALCL had methotrexate-induced nephrotoxicity following high-dose methotrexate. The resultant delayed methotrexate clearance required the standard therapies as well as use of investigational CPDG(2). High-dose methotrexate was successfully resumed.
This paper reports the findings of a study involving the selection process that adult graduate students used when choosing to pursue and attain an advanced business degree at Southern Wesleyan University. This study includes a comparison of the initial priorities used in the selection process to priorities that remain important in retrospect. The study also includes a comparison of the schools stated program objectives to the reasons for students program selection. A two-tailed analysis of data supplied by 184 respondents revealed there was no significant difference between student responses at the beginning of the program and student responses at the conclusion of the program. The study also reveals a close alignment between the schools program objectives and some of the highest ranked priorities given by the students for choosing the programs. The four (4) highest ranked priorities at the beginning and at the end of the program included Fits my schedule, Job advancement/marketability, Received undergraduate degree from SWU, and Christian perspective. These results can assist University administrators, managers, and recruiters in adapting their marketing strategies to provide critical and relevant information to prospective students. The study did not consider demographics as a component of the selection process or with the schools stated program objectives.
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