Polymeric
nanoparticles have become indispensable in modern society
with a wide array of applications ranging from waterborne coatings
to drug-carrier-delivery systems. While a large range of techniques
exist to determine a multitude of properties of these particles, relating
physicochemical properties of the particle to the chemical structure
of the intrinsic polymers is still challenging. A novel, highly orthogonal
separation system based on comprehensive two-dimensional liquid chromatography
(LC × LC) has been developed. The system combines hydrodynamic
chromatography (HDC) in the first-dimension to separate the particles
based on their size, with ultrahigh-performance size-exclusion chromatography
(SEC) in the second dimension to separate the constituting polymer
molecules according to their hydrodynamic radius for each of 80 to
100 separated fractions. A chip-based mixer is incorporated to transform
the sample by dissolving the separated nanoparticles from the first-dimension
online in tetrahydrofuran. The polymer bands are then focused using
stationary-phase-assisted modulation to enhance sensitivity, and the
water from the first-dimension eluent is largely eliminated to allow
interaction-free SEC. Using the developed system, the combined two-dimensional
distribution of the particle-size and the molecular-size of a mixture
of various polystyrene (PS) and polyacrylate (PACR) nanoparticles
has been obtained within 60 min.
A range
of poly(ethylene glycol) (PEG)-based polyacrylate networks
with two different topological properties were synthesized by photoinitiated
free-radical polymerization and analyzed by mechanical, chromatographic,
and NMR methods. Comparison between networks with ziplike and pointlike
junctions pinpointed the critical role of network topology in generating
the so-called “short chain abnormality” in polymer dynamics.
In particular, double quantum (DQ) NMR analysis of the ziplike networks
identified strong topological constraints on isotropic movement of
network chains directly resulting in increased effective functionality
of the system. The failure of classical rubber elasticity theory in
treating networks with ziplike cross-links is found to arise primarily
from non-Gaussian behavior of these network chains caused by the topological
constraints.
Polyesters obtained by the catalytic ringopening polymerization of macrolactones in many aspects resemble the properties of polyethylene. However, the molecular weight distribution is intrinsically different and equals the molecular weight distribution observed for a stepgrowth process even though macrolactone ring-opening polymerization follows a chain-growth mechanism. The concurrent occurrence of transesterification reactions leading to the formation of cyclic polymers is responsible for the deviation from the molecular weight distribution characteristic for chain-growth polymerization. To explain and extent on the theoretical principles forming the basis of this peculiar molecular weight distribution, in this work the cyclization process during the polymerization of the 17-membered macrolactone ambrettolide has been analyzed. Liquid chromatography under critical conditions has been applied to semiquantitatively analyze the fractions of cyclic and linear products. In addition, low molecular weight size exclusion chromatography has been used to independently quantify the fractions of the smallest cyclics. Using the combination of these techniques it has been shown that cyclics are present during the whole polymerization process. Furthermore, the thermodynamics of the polymerization reaction were determined. The negligible ΔH ⊖ p = 0.9 ± 1.9 kJ•mol −1 and a positive ΔS ⊖ p = 38.5 ± 6.5 J•mol −1 •K −1 clearly demonstrate the absence of significant ring strain and proofs that the polymerization is driven by entropy. Individual equilibrium concentrations of the cyclics, from monomer to pentamer, were determined and these values were used in combination with the Jacobson and Stockmayer theory to calculate the effective molarity of the cyclic monomer, B = 0.087 M. This value subsequently yields a critical monomer concentration of 0.155 M, for which it was also experimentally determined that polymerizations having a monomer concentration below this value only yield cyclic polymers. Finally, B was used in combination with the monomer and initiator concentration to successfully predict the molecular weight distribution, which shows that real M n 's are far lower and dispersities far higher than predicted from often-applied theories.
Accurate quantification of polymer distributions is one of the main challenges in polymer analysis by liquid chromatography. The response of contemporary detectors is typically influenced by compositional features such as molecular weight, chain composition, end groups, and branching. This renders the accurate quantification of complex polymers of which there are no standards available, extremely challenging. Moreover, any (programmed) change in mobile‐phase composition may further limit the applicability of detection techniques. Current methods often rely on refractive index detection, which is not accurate when dealing with complex samples as the refractive‐index increment is often unknown. We review current and emerging detection methods in liquid chromatography with the aim of identifying detectors, which can be applied to the quantitative analysis of complex polymers.
The thermal polymerization reaction of divinyl siloxane bis-benzocyclobutene (DVS bis-BCB) was monitored in-situ with FT-IR spectroscopy in order to follow specific chemical changes and determine the reaction order and rate constants at temperatures from 150° to 210°C. FT-IR spectra were obtained at regular intervals throughout the reaction with a Nicolet 170SX spectrophotometer.Monomeric DVS bis-BCB contains mixed stereo and positional isomers of 1,3- bis(2-bicyclo[4.2.0]octa-1, 3, 5-trien-3-ylethenyl)-1, 1, 3, 3-tetramethyl disiloxane (CAS 117732-87-3). It polymerizes via Diels-Alder cycloaddition reactions between vinyl groups and an intermediate o-quinodimethane formed by first-order, thermally initiated ring openings of the benzocyclobutene rings. Gaseous byproducts are not produced; therefore, the cure is easier to manage than are cures for polyimides which evolve water in polycondensation reactions. The DVS bis-BCB has four reactive elements per monomer unit and, thus, polymerizes into a very highly cross linked and solvent resistant network.With the FT-IR methodology, the reaction was easily monitored through the points of gel formation and vitrification. With the exception of DSC (i.e., calorimetry) which does not sense specific chemistry, other methods were not successful in following the reaction after a gel was formed. We have found that the polymerization was first-order until vitrification occurs; the gelation alone had no apparent effect on the reaction rate.DVS bis-BCB is under development at Dow as high performance dielectric material for multilayer interconnect coating applications for the microelectronics industry. Methodology reported here is employed in developing effective cure management strategies.
The results of three experimental studies, i.e. GC‐MS of peroxide‐cross‐linked alkene/alkane mixtures, 13C NMR of peroxide‐cured, 13C‐labeled 2‐ethylidene‐5‐norbornene ‐ ethylene‐propylene‐diene‐monomer (EPDM) and EPR of peroxide curing of EPDM, are combined, yielding a more accurate description of the mechanism of peroxide cure of EPDM. Both alkyl and allyl macro‐radicals are formed via H‐abstraction from the EPM main chain and the residual diene unsaturation, respectively. Combination of these macro‐radicals yields alkyl/alkyl, alkyl/allyl and allyl/allyl cross‐links and addition of these macro‐radicals to the residual diene unsaturation yields alkyl/alkene and allyl/alkene cross‐links.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.