RESUME : A partir des 5 -, 6-et 7-fluoroisatines, on decrit la synthese des 9-, 10-et 11-fluoroacronycines via les 5 -, 6-et 7-fluoro-1,3-dihydroxy-lO-m6thylacridan-9-ones.SUMMARY : An unambiguous synthesis of 9-, 10-and 11-fluoroacronycines is described starting from 5-, 6-and 7-fluoroisatines.L'acronycine o u acronine est un alcaloide dont la structure est celle de la 3,12-dihydro-6-m~thoxy-3,3,12-trimbthyl-7H-pyranno [ 2,3-c
13C Nuclear magnetic resonance studies of proline peptides with central antalgic activity (Pro-Arg, Arg-Pro, Pro-Arg-Pro, Pro-Lys-Pro) indicate a predominance of trans conformation at all pH values; but their physiological activities appear to be related to the ability of the C-terminal proline peptides to assume the cis conformation.
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