Background: Overall health of middle-aged women have become a major public health concern, there is therefore a need to evaluate the effectiveness of comprehensive nursing intervention program with the intention of reducing their symptom experience and increasing their health-related quality of life. Aims: The aim of the study was to assess the effectiveness of comprehensive nursing intervention program on reducing the symptom experience and increasing their health related quality of life. Methodology: Menopausal Rating Scale (MRS) was used for assessing postmenopausal symptoms and WHOQOL-BREF quality of life scale was used for assessing quality of life of postmenopausal women. 60 post menopausal women attending at B.V.V.Sangha’s Akkanabalaga Bagalkot were selected for the study using Simple random technique with Lottery method and then 30 post menopausal women were randomly assigned to experimental and control group respectively using computer generated random sequence. Data were analyzed using SPSS 25v. Findings: Findings related to significance of difference between post-test symptom experience and health related quality of life scores of experimental group and control group postmenopausal women revealed that, there was a significant difference between the post test symptom experience scores of experimental group and post test symptom experience scores of control group [t=26.052, p=0.000]. Similarly, there was significant difference between post test health related quality of life scores of experimental group and post test health related quality of life scores of control group [t= 23.117,p=0.000]. Conclusion: The study concluded that the comprehensive nursing intervention was highly effective in reducing the symptom experience and health related quality of life scores of post menopausal women. Keywords: Symptom Experience, Quality of Life, Postmenopausal Women, Comprehensive Nursing Interventions.
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