The ethanolic extract of seeds of Cuminum cyminum (C.c) was found to improve glucose tolerance to the tune of around 18.3% (P \ 0.01) in normal rats and shows around 17.7% (P \ 0.01) and 17.1% fall on blood glucose levels at 0-300 and 0-1440 min, respectively, on streptozotocin-induced diabetic rats at an oral dose of 250 mg/Kg body weight. The extract has also been found to improve around 26.7% (P \ 0.01) glucose intolerance on 14th day post treatment in high fructose fed streptozotocininduced diabetic rats. The extract was also found to have antidyslipidemic activity as evident by 21.04% (P \ 0.01) decline in serum triglycerides, 22.7% (P \ 0.01) decline in total serum cholesterol, and 16.9% of decline in serum LDL-C, respectively, along with 12.2% (P \ 0.05) increase in serum HDL-C on high fat diet fed male Syrian golden hamster. The extract was also found inhibitory to eye lens aldose reductase (EC 1.1.1.21) with IC 50 value of 7.07 lg/ml as compared to the standard AR inhibiting compound Quercetin which showed IC 50 2.35 lg/ml. The extract was also found inhibitory to a-glucosidase with IC 50 value of 100 lg/ml as compared to known drug Acarbose which showed IC 50 of around 25 lg/ml.
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