Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models

Abstract

The ethanolic extract of seeds of Cuminum cyminum (C.c) was found to improve glucose tolerance to the tune of around 18.3% (P \ 0.01) in normal rats and shows around 17.7% (P \ 0.01) and 17.1% fall on blood glucose levels at 0-300 and 0-1440 min, respectively, on streptozotocin-induced diabetic rats at an oral dose of 250 mg/Kg body weight. The extract has also been found to improve around 26.7% (P \ 0.01) glucose intolerance on 14th day post treatment in high fructose fed streptozotocininduced diabetic rats. The extract was also found to have antidyslipidemic activity as evident by 21.04% (P \ 0.01) decline in serum triglycerides, 22.7% (P \ 0.01) decline in total serum cholesterol, and 16.9% of decline in serum LDL-C, respectively, along with 12.2% (P \ 0.05) increase in serum HDL-C on high fat diet fed male Syrian golden hamster. The extract was also found inhibitory to eye lens aldose reductase (EC 1.1.1.21) with IC 50 value of 7.07 lg/ml as compared to the standard AR inhibiting compound Quercetin which showed IC 50 2.35 lg/ml. The extract was also found inhibitory to a-glucosidase with IC 50 value of 100 lg/ml as compared to known drug Acarbose which showed IC 50 of around 25 lg/ml.

Bioreactive Compounds and Antioxidant Properties of Methanolic Extract of Fennel (Foeniculum Vulgare Miller)

“…Deleterious impact of oxidative stress in biological systems is related to the damage of proteins, enzymes 20 and various transcriptional factors like NFkB and AP-1 21 . Oxidation of the sulphydryl groups of cysteine to cystine may cause changes in the structure and functions of the proteins.…”

Effects of cumin (Cuminum cyminum L.) essential oil supplementation on metabolic syndrome components: A randomized, triple‐blind, placebo‐controlled clinical trial

“…Cuminaldehyde, the major component in green cumin, has inhibitory effects on carbohydrate digestion enzymes including a-glycosidase and adlose reductase (Srivsatava et al, 2011) and is identified as potent insulinotrophic and β-cell protective component (Patil, Takalikar, Joglekar, Haldavnekar, & Arvindekar, 2013).…”

Chalcone-Based Aryloxypropanolamine as a Potential Antidiabetic and Antidyslipidaemic Agent

“…Blood glucose profile of each rat was determined just prior to the administration of test sample (-30 min), sucrose (0 min) and thereafter at 30, 60, 90 and 120 min post administration of sucrose by the glucometer. Food but not water was withdrawn from the cages during the course of experimentation 16 . Quantitative inhibition on the rise of postprandial hyperglycaemia post sucrose load by the test sample was calculated by plotting duration and blood glucose level on the x-and y-axis respectively.…”

“…The biological studies of compound 3 and its enantiomers are presented here. The enantiomers of compound 3 have been obtained by asymmetric synthesis with optically pure epichlorohydrins following the protocol used earlier for atenolol, a -blocker drug 16 . In the method, hydroxyl-chalcone (6) obtained by the condensation of 4-hydroxy-acetophenone (4) and piperonal (5) was heated at ~100-120C with either R-or S-epichlorohydrin to give chlorohydrin intermediates 7a or 7b (Scheme 1), which were then cyclized in situ under basic conditions (aq.…”