Metastases from pancreatic malignancy are commonly known to occur in the regional lymph nodes, liver, lung, and peritoneum. Synchronous or metachronous metastasis from the pancreas to the colon is rare, with only 6 cases reported in the literature. We report a man who was found to have adenocarcinoma on biopsies from synchronous lesions in the colon and the pancreas. The immunohistochemistry report revealed the diagnosis of a primary pancreatic malignancy with synchronous colonic metastases.
IgG4-related disease of the stomach is a rare disorder, and only a few cases have been reported. We present two cases that were identified over a 2-month period in our center. Two male patients aged 52 and 48 years presented with mass lesion in the stomach, which were clinically thought to be gastrointestinal stromal tumor, and they underwent excision of the lesion. Microscopic examination revealed marked fibrosis, which was storiform in one case, associated with diffuse lymphoplasmacytic infiltration and an increase in IgG4positive plasma cells on immunohistochemistry. Serum IgG4 level was markedly elevated. Although rare, IgG4-related disease should be considered in the differential diagnosis of gastric submucosal mass lesions.
Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage renal disease (ESRD), accounting for more than 50% of all deaths. Highsensitivity troponin T (hsTnT) assay is a sensitive and specific marker of myocardial injury and necrosis. Objective: The objective of this study was to evaluate the prognostic role of elevated hsTnT levels in identifying ESRD patients with high risks of developing cardiovascular morbidity or mortality. Materials and methods: The present study was a crosssectional observational study conducted in 50 patients fulfilling the prespecified inclusion criteria. Patients were evaluated based on the history, clinical findings, lab investigations including hsTnT, two-dimensional echocardiogram, and duration and frequency of hemodialysis (HD). Results: The study cohort showed significant correlation of elevated hsTnT levels with left ventricular hypertrophy (p < 0.05), diabetes mellitus (p < 0.005), duration of HD (p < 0.01), and mortality (p < 0.05). Conclusion: Troponin T is a promising prognostic tool, since elevated levels identify a subset of ESRD patients who have poor survival and higher risk of death. Though sample size was small, this study corroborates previous postulates on this subject. However, being a small sample study, findings could not be subjected to a larger population.
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