No abstract

Background We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients. Methods The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death.

The Pilocarpus microphyllus Stapf ex Wardlew specie is a native plant from north and northeast of Brazil occurring in eastern of Pará state, northwest and north of Maranhão and Piauí. It is one of the most important Brazilian medicinal species presents in pharmacopoeia of the entire world due to the use of its active pilocarpine. When using the Web of Science periodic base with Pilocarpus genus the result was 56 articles and for the specie Pilocarpus microphyllus the result found was 17 articles. The search for patents was using the basic patent Derwent Innovation Index, INPI, EPO and USPTO getting a contrasting result with the number of articles, recital Japan highlighted in protection of research involving Pilocarpus. The genus Pilocarpus with emphasis on Pilocarpus microphyllus specie through published articles and patents granted in Brazil and in other countries highlights the economic and industrial importance of the specie and provides future perspectives in the discovery of new pharmacological and biotechnological applications of the others alkaloids which so far remains unknown.

No abstract

RESUMO A Natura é uma das marcas brasileiras de cosméticos mais conhecida na América Latina e no mundo. Nos últimos anos cresceu ao adquirir a Avon, tendo consumidores em cerca de 63 países diretamente e indiretamente, por abranger um público amplo de consumidores através da qualidade dos seus produtos e da busca pela preservação do meio ambiente. O objetivo do presente trabalho é mostrar como a organização atua em seus programas de sustentabilidade e em sua logística reversa, criando um valor com a sociedade como um todo e reduzindo o efeito estufa que vem atingindo o planeta de forma temerosa. Além disso, é mostrada a atual situação do cenário mundial com a pandemia do Coronavírus que criou uma crise econômica, principalmente no setor da beleza, em que muitos consumidores trocaram a maquiagem pela máscara de proteção. Assim, a Natura foi obrigada a readequar suas atividades para esse momento. É essencial a atuação de seus clientes e fornecedores para a realização desses projetos. A partir de uma análise realizada com o apoio dos consumidores e colaboradores, podemos compreender que a empresa não busca somente a melhora do impacto econômico, mas também o desenvolvimento social, ambiental e cultural como ferramentas para seu crescimento. Palavras-chave: Desenvolvimento Sustentável. Meio Ambiente. Logística Reversa. Reciclagem.