The value of open-source clinical science in pandemic response: lessons from ISARIC

Association Between Sex Hormone Levels and Clinical Outcomes in Patients With COVID-19 Admitted to Hospital: An Observational, Retrospective, Cohort Study

“…Data up to discharge from hospital or death during hospitalization were gathered from health records in a predefined electronic database. The IRCCS Sacro Cuore Don Calabria Hospital adopted the case report form developed by the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) and WHO for use in outbreak investigations ( 15 ); the San Gerardo Hospital developed an ad-hoc platform on the basis of WHO COVID-19 (COVID-STORM, ClinicalTrials.gov:NCT04424992).…”

A comparison of four epidemic waves of COVID-19 in Malawi; an observational cohort study

“…Policy makers need robust data to inform the clinical and public health response to the COVID-19 pandemic. The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) has developed a variety of tools and protocols to support the collection and analysis of data during the pandemic (1)(2)(3). These simplify the establishment of observational cohorts, and enable high-quality, harmonised, clinical research in response to emerging threats.…”

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

“…The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) is a global federation of clinical research networks collaborating to prevent illness and death from infectious disease outbreaks through proficient and agile research response 1 . In January 2020, ISARIC launched a research response to the emergence of a novel severe acute respiratory syndrome coronavirus (SARS-COV-2), detected weeks earlier in Wuhan, China 2 , 3 .…”

“…At the beginning of the COVID-19 outbreak, ISARIC adapted the ISARIC-WHO Clinical Characterization Protocol and data tools 7 to facilitate global research collaboration and accelerate the understanding of COVID-19 as part of the public health response to the pandemic 1 , 8 , 9 . Between January 2020 and September 2021, information about the clinical presentation, treatment, and outcomes of more than 705,000 patients with COVID-19, hospitalized across 62 countries, was aggregated to form the ISARIC-COVID-19 dataset.…”