The performance and normative values obtained for this low-cost water-perfused HRM seems to be adequate for clinical use.
Background: High-resolution manometry is more costly but clinically superior to conventional manometry. Water-perfused systems may decrease costs, but it is unclear if they are as reliable as solid-state systems, and reference values are interchangeable. Aim: To validate normal values for a new water-perfusion high-resolution manometry system. Methods: Normative values for a 24-sensors water perfused high-resolution manometry system were validated by studying 225 individuals who underwent high resolution manometry for clinical complaints. Patients were divided in four groups: group 1 - gastroesophageal reflux disease; group 2 - achalasia; group 3 - systemic diseases with possible esophageal manifestation; and group 4 - dysphagia. Results: In group 1, a hypotonic lower esophageal sphincter was found in 49% of individuals with positive 24 h pH monitoring, and in 28% in pH-negative individuals. In groups 2 and 3, aperistalsis was found in all individuals. In group 4, only one patient (14%) had normal high-resolution manometry. Conclusions: The normal values determined for this low-cost water-perfused HRM system with unique peristaltic pump and helicoidal sensor distribution are discriminatory of most abnormalities of esophageal motility seen in clinical practice.
RESUMOObjetivo: Avaliar o perfil dos pacientes com neoplasia maligna de estômago, que receberam atendimento e tratamento no Hospital Municipal Dr. Jose de Carvalho Florence (HMJCF). Métodos: Estudo retrospectivo a partir do levantamento de prontuários. Análises foram feitas com uma amostragem e proporções esperadas desiguais e Quadros de contingência. Para se verificar associação entre as variáveis, utilizado o teste Qui–Quadrado de Pearson, considerando-se p ≤ 0,05, em um grau de confiabilidade de 95%. Resultados: O sexo masculino é o com maior número de casos na proporção de 2:1. A idade média ao diagnóstico é 65,16 anos. A queixa mais comum apresentada por estes pacientes foi a epigastralgia seguido pela inapetência. A maioria dos tumores encontrava-se no antro gástrico. Cinquenta e nove destes pacientes foram submetidos a cirurgia sendo 45 com intuito curativo. A sobrevida média foi de 15 meses e a taxa de sobrevida em 5 anos de apenas 6%. Conclusão: O CG é uma doença muito agressiva e de prognóstico ruim. Suas manifestações iniciais são inespecíficas, o que torna seu diagnóstico em fases iniciais muito difícil.Palavras chave: Câncer Gástrico, Úlcera gástrica, Perfil de SaúdeABSTRACTObjective: Evaluate the profile of patients with malignant neoplasia of stomach, receiving care and treatment in Hospital Municipal Dr. Jose de Carvalho Florence (HMJCF). Methods: Retrospective study based on a survey of medical records. Analysis were made with a sampling and unequal expected ratios and contingency tables. To assess the association between variables, will be used the chi-square test, considering p ≤ 0.05, at a reliability level of 95%. Results: The largest number of cases are male, ratio of 2:1. The average age at diagnosis is 65.16 years. Caucasians followed by mulatto were the most frequent with Gastric Cancer. The most common complaint presented by these patients was abdominal pain followed by loss of appetite. Most tumors found in the gastric antrum. Fifty-nine of these patients underwent surgery with curative intent in 45. Twenty of them had some type of metastasis intraoperatively and 12 outpatients progressed to metastatic lesions. The median survival was 15 months and the survivor rate in 5 years was only 6%. Conclusion: The Gastric Cancer is a very aggressive and poor prognosis disease. Its initial symptoms are nonspecific, making diagnosis difficult in the early stages.Keywords: Gastric Cancer, Gastric Ulcer, Health Profile.
The Chicago Classification has been the leading guideline for esophageal motility disorders evaluation and classification since the advent of high-resolution manometry. Esophagogastric junction (EGJ) barrier function was neglected until the most current update of the classification when a technical review on the topic was recently released (1) . In this publication, the Contractility Integral of the Esophagogastric Junction (EJG-CI) was deemed "currently the best validated metric of EGJ contractile vigor and should be adopted".Each manometry system has different reference values depending on its operating mechanism. This is mainly visible in water perfusion systems, where the response of the sensors is slower, given the latency of the response time to the passage of water through the sensors. We have published normative values for a
Introdução: A osteoporose é considerada um grave problema de saúde pública em todo o mundo. No Brasil ainda não há dados estatísticos sobre a real incidência desta doença. Os glicocorticóides representam uma classe de drogas muito usada, sendo que podem influenciar significativamente a massa óssea. Entretanto, após tratamento com glicocorticóides em ratos, esses podem ou não apresentar alterações na massa óssea. Objetivo: Avaliar a eficácia da administração de dexametasona ou metilprednisolona em produzir osteoporose em ratas. Métodos: Vinte e quatro ratas, oriundas do biotério da Faculdade de Medicina de Itajubá, foram utilizadas e divididas em três grupos: controle, metilprednisolona e dexametasona. Foram avaliados íons e proteínas totais sanguíneos e feita a análise histopatológica de tecido ósseo. Resultados e conclusão: Pela análise histológica da espessura trabecular óssea, houve redução da massa óssea dos grupos tratados com glicocorticóides em comparação com o grupo controle, evidenciando o sucesso da indução de osteoporose. Além disso, houve uma maior redução da massa óssea no grupo tratado com dexametasona, em comparação com o grupo tratado com metilprednisolona. A análise bioquímica de cálcio, fósforo, magnésio e proteínas totais não sofreram diferença significativa entres os grupos, não sendo um bom marcador para remodelamento ósseo e para diagnóstico de osteoporose.Evaluating the Effectiveness of Dexamethasone or Methylprednisolone to Produce Osteoporosis in RatsIntroduction: Osteoporosis is considered a serious public health problem in worldwide. In Brazil we do not have statistics on the real disease incidence. Glucocorticoids are a class of drugs widely used, and can significantly influence bone mass. However, after treatment with glucocorticoids in rats, these may or may not show changes in bone mass. Objective: Evaluating the effectiveness of dexamethasone or methylprednisolone to produce osteoporosis in rats. Methods: Twenty-four rats, originated from the vivarium of the Faculty of Medicine Itajubá were used and divided into three groups: control, methylprednisolone and dexamethasone. Ions was evaluated blood and histopathology of bone tissue. Results and conclusion: by histologic analysis of trabecular bone thickness, a reduction of the mass bone in the groups treated with glucocorticoids compared with the group control, demonstrating the successful induction of osteoporosis. Furthermore, there was a greater reduction in bone mass in the group treated with dexamethasone compared with the group treated with methylprednisolone. The analysis biochemistry of calcium, phosphorus, magnesium and total protein did not undergo significant difference among the groups, there is a good marker for bone remodeling and osteoporosis diagnosis.
Objetivo: Analisar a distribuição sazonal e espacial dos traumas, aliados à avaliação das características das vítimas envolvidas e os tipos de chamadas relacionadas ao trauma. Materiais e Métodos: As informações foram colhidas a partir do banco de dados do corpo de bombeiros de Itajubá (9ºBBM) referentes ao período de 1 de janeiro de 2003 à 31 de dezembro de 2010 (n=51536). Resultados: O número de traumas corresponde a 11% (n=5092) do total de atendimentos realizados no período estudado, sendo os acidentes de trânsito os principais responsáveis pelas ocorrências (55%). O sexo masculino na faixa etária de 30-50 anos é o perfil mais característico das vítimas, e o final da tarde o período com maior concentração de traumas. Em relação a distribuição semanal, o final de semana possui a grande maioria das ocorrências e o mês de junho é ligeiramente o mais acometido. Conclusão: Esse conhecimento detalhado das vítimas pode repercutir na melhora e no direcionamento do Atendimento Pré-Hospitalar (APH), tanto na fase pré, quanto intra-hospitalar, além de subsidiar decisões estratégicas na gestão do trânsito e da saúde pública.Palavras-chave: Trauma, Bombeiro, Atendimento Pré-HospitalarABSTRACTObjective: To evaluate the seasonal and spatial distribution of the traumas, together with the analysis of the characteristics of the victims and the kind of call related to the trauma. Materials and Methods: The information was collected from the database of the firefighters corporation of Itajubá (9ºBBM) referring to the period from January 1st, 2003 to December 31st, 2010 (n= 51536). Results: The number of traumas correspond to 11% (n=5092) of total calls. Traffic accidents were the biggest causes for the occurrences (55%). Individuals predominantly from the masculine gender, 30-50 years old is the profile that mostly characterized the victims, and the end of the afternoon is the period with the biggest concentration of traumas. Conclusion: Knowing the profile of victims could have an effect on improving care and directing treatment in the Pre- Hospital Attendance (PHA) both pre and intra-hospital, in addition to supporting strategic decisions on traffic management and public health.Keywords: Trauma, Firefighter, Pre-hospital Attendance
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