Background: Control of coronavirus infection 2019 outbreaks lack specific vaccine or drugs, highlighting the need for appropriate interventions. Indigenous knowledge has been a source of medicinal agents for thousands of years and could help to circumvent this threat. We sought to know the current indigenous knowledge used by people living in Yaounde and Douala, Cameroon to protect against covid-19.Methods: This survey was conducted with twohundred and seventy-seven participants. A semistructured questionnaire aiming at understanding of the practice and common interventions use by people to prevent covid-19 infection. Interviews were conducted by telephone and face to face interviews.Results: A total of thirty-nine recipes consisting in thirty-eight distinct ingredients were recorded. The recipe ingredients comprising twenty-nine medicinal plants and nine other alternatives were used for covid-19 prevention in the city of Yaounde and Douala, Cameroon. The twenty-nine medicinal plant species corresponded to twenty-eight genera, arranged in twenty plant families. The most cited plants in recipes were Citrus aurantiifolia Christm., Zingiber officinale Roscoe, and Allium sativum L.. The most cited formulation besides the basic protective measures consisting in recipe 6 [Allium sativum L., Citrus aurantiifolia (Christm.) Swingle.and Zingiber officinale Roscoe (RFC=Relative frequency of citation 15.16%)]. Leaves were the most commonly utilized plant part with a frequency of 45%. From the thirty-nine recipes recorded, majority were decoction (69.23%; 27/39) and were administered orally.
Conclusions:Results show common knowledge devoid of scientific proof for most hints. Thus, their clinical application is pending reasonable scientific data on recipes and their standardization to support safety and efficacy in humans.
Background: The increasing incidence of dermatophytoses in the world and the side effects of the current therapies encouraged the search of alternative drugs. Hence the objective of this work was to determine antidermatophytes activity of Syzigium aromaticum formulate antidermatophytic cream. Materials and Methods: The extracts were prepared by maceration of plant materials into methanol. Three formulations of creams were made, and the best was chosen according to its physicochemical stability and appearance. The acute dermal toxicity and antidermatophytic efficacy of the cream was performed on guinea-pig. Results: The methanolic extract of S. aromaticum was incorporated in the final cream formulation. The formulation containing shea-butter 58.5%, acetylic alcohol 2.5%, stearic acid 1.5%, bee-wax 10%, borax 1.5%, polysorbate 60 2.5%, 2 drops of lactic acid and water was chosen because of its good appearance and stability. The cream with methanolic extract of S. aromaticum did not reveal any dermal toxic effect. The cream efficacy was dose-dependent. The treatment with cream at 5% methanolic extracts of S. aromaticum revealed the best potency after 14 days of treatment. Conclusion: These results show that the cream at 5% methanolic extract of S. aromaticum seed is promising in the treatment of dermatophytoses and could be used as an alternative in the development of a new therapy.
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