The solubility of paracetamol (4-hydroxyacetanilide) in 26 solvents in the temperature range from −5 to
+30 °C is reported. Paracetamol has a very low solubility in nonpolar and chlorinated hydrocarbons
such as toluene and carbon tetrachloride whereas the solubility is very high in solvents of medium polarity
such as N,N-dimethylformamide, dimethyl sulfoxide, and diethylamine. Paracetamol is soluble in alcohols,
but the solubility decreases with an increase in the length of the carbon chain in the n-alcohol homologous
series (methanol to 1-octanol). The solubility of paracetamol in water is much lower than in other polar
solvents such as the alcohols. The ideal solubility of paracetamol is calculated, and the activity coefficient
in the saturated solutions is estimated.
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