Solubility of Paracetamol in Pure Solvents

Granberg, Roger A.; Rasmuson, Åke C.

doi:10.1021/je990124v

Cited by 338 publications

(294 citation statements)

References 7 publications

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“…UV− vis experiments conducted on the supernatant of PVA−MNP fibers stored in absolute ethanol for 4 weeks showed no traces of Fe 3 O 4 leaching (Supporting Information Figure S2). Acetaminophen was chosen as a model drug for this study due to its high solubility in ethanol 58 and its characteristic UV− vis absorption. 59 This drug was effectively immobilized onto the PVA−MNP fibers ( Figure 4A), following which the drug−fiber system was transferred to an absolute ethanol medium and studied for the release of acetaminophen with time, both with and without magnetic actuation ( Figure 4B,C and Supporting Information Videos S2 and S3).…”

Section: Resultsmentioning

confidence: 99%

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Perera

Zhang

Homer‐Vanniasinkam

et al. 2018

ACS Appl. Mater. Interfaces

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An efficient method is reported, for the fabrication of composite microfibers that can be magnetically actuated and are biocompatible, targeting controlled drug release. Aqueous solutions of polyvinyl alcohol, incorporated with citric acid-coated Fe 3 O 4 magnetic nanoparticles (MNPs), are subject to infusion gyration to generate 100− 300 nm diameter composite fibers, with controllable MNP loading. The fibers are stable in polar solvents, such as ethanol, and do not show any leaching of MNPs for over 4 weeks. Using acetaminophen as an example, we demonstrate that this material is effective in immobilization and triggered release of drugs, which is achieved by a moving external magnetic field. The remote actuation ability, coupled with biocompatibility and lightweight property, renders enormous potential for these fibers to be used as a smart drug release agent.

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Section: Resultsmentioning

confidence: 99%

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Perera

Zhang

Homer‐Vanniasinkam

et al. 2018

ACS Appl. Mater. Interfaces

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“…The solubility measurements were carried out by using a gravimetric method [5]. It consists in preparing saturated solutions of racemic ketoprofen in different solvents, which are placed in a thermostatic water bath at a constant temperature of 25 • C. After equilibration, a volume of 5 cm 3 of the clear saturated solution is transferred to a previously weighed glass vial of mass m V .…”

Section: Solubility Measurementsmentioning

confidence: 99%

Preparative separation of ketoprofen enantiomers: Choice of mobile phase composition and measurement of competitive adsorption isotherms

Ribeiro

Graça

Pais

et al. 2008

Separation and Purification Technology

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The present work intends to investigate how mobile phase composition influences the adsorption behavior of ketoprofen enantiomers (a nonsteroidal anti-inflammatory drug) on an amylose-based chiral stationary phase (Chiralpak AD). Three mobile phase compositions were studied: the usual 20% ethanol/80% n-hexane mixture and two pure mobile phases; methanol and ethanol. Pulse and breakthrough experiments under preparative conditions were carried out in order to measure and test adsorption isotherms. The results obtained show that, for preparative separations, pure ethanol is a better mobile phase than the usual 20% ethanol/80% n-hexane mixture: it allows higher solubility of the racemate, lower retention times, and also a higher selectivity at high enantiomer concentrations. These are aspects of crucial importance when the final goal is to achieve high productivity preparative separations, as it is shown for the simulated moving bed (SMB) operation.

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“…The dispersed and continuous phase of desired formulation (Table 1) water is 10.7 and 17.4 g/kg, respectively. 38 The cumulative release was determined by:…”

Section: Introductionmentioning

confidence: 99%

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

Ekanem

Nabavi

Vladisavljević

et al. 2015

ACS Appl. Mater. Interfaces

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Biodegradable poly(DL-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) microparticles with tunable size, shape, internal structure and surface morphology were produced by counter-current flow focusing in axisymmetric (3D) glass capillary devices. The dispersed phase was composed of 0.5-2 wt% polymer solution in a volatile 2 organic solvent (ethyl acetate or dichloromethane) and the continuous phase was 5 wt% aqueous poly(vinyl alcohol) solution. The droplets with a coefficient of variation in dripping regime below 2.5 % were evaporated to form polymeric particles with uniform sizes ranging between 4-30 µm. The particle microstructure and surface roughness were modified by adding nanofiller (montmorillonite nanoclay) or porogen (2-methylpentane) in the dispersed phase to form less porous polymer matrix or porous particles with golf-ball-like dimpled surface, respectively. The presence of 2-4 wt% nanoclay in the host polymer significantly reduced the release rate of paracetamol and prevented the early burst release, as a result of reduced polymer porosity and tortuous path for the diffusing drug molecules. Numerical modelling results using the volume of fluid-continuum surface force model agreed well with experimental behaviour and revealed trapping of nanoclay particles in the dispersed phase upstream of the orifice at low dispersed phase flow rates and for 4 wt% nanoclay content, due to vortex formation. Janus PLA/PCL (polycaprolactone) particles were produced by solvent evaporation-induced phase separation within organic phase droplets containing 3 % (v/v) PLA/PCL (30/70 or 70/30) mixture in dichloromethane. A strong preferential adsorption of Rhodamine 6G dye onto PLA was utilized to identify PLA portions of the Janus particles by Confocal Laser Scanning Microscopy (CLSM). Uniform hemispherical PCL particles were produced by dissolution of PLA domes with acetone.

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Solubility of Paracetamol in Pure Solvents

Cited by 338 publications

References 7 publications

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Preparative separation of ketoprofen enantiomers: Choice of mobile phase composition and measurement of competitive adsorption isotherms

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

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