Planar in vitro models have been invaluable tools to identify the mechanical basis of wound closure. Although these models may recapitulate closure dynamics of epithelial cell sheets, they fail to capture how a wounded fibrous tissue rebuilds its 3D architecture. Here we develop a 3D biomimetic model for soft tissue repair and demonstrate that fibroblasts ensconced in a collagen matrix rapidly close microsurgically induced defects within 24 h. Traction force microscopy and time-lapse imaging reveal that closure of gaps begins with contractility-mediated whole-tissue deformations. Subsequently, tangentially migrating fibroblasts along the wound edge tow and assemble a progressively thickening fibronectin template inside the gap that provide the substrate for cells to complete closure. Unlike previously reported mechanisms based on lamellipodial protrusions and purse-string contraction, our data reveal a mode of stromal closure in which coordination of tissue-scale deformations, matrix assembly and cell migration act together to restore 3D tissue architecture.

Industrial standards define safety requirements for Human-Robot Collaboration (HRC) in industrial manufacturing. The standards particularly require real-time monitoring and securing of the minimum protective distance between a robot and an operator. In this work, we propose a depth-sensor based model for workspace monitoring and an interactive Augmented Reality (AR) User Interface (UI) for safe HRC. The AR UI is implemented on two different hardware: a projector-mirror setup and a wearable AR gear (HoloLens). We experiment the workspace model and UIs for a realistic diesel motor assembly task. The AR-based interactive UIs provide 21-24% and 57-64% reduction in the task completion and robot idle time, respectively, as compared to a baseline without interaction and workspace sharing. However, subjective evaluations reveal that HoloLens based AR is not yet suitable for industrial manufacturing while the projector-mirror setup shows clear improvements in safety and work ergonomics.

A magnetoelectric micromachine manipulated by magnetic field for both locomotion and on-demand function triggering enlighten the concept of unisource-powered microdevices.

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We introduce the modelling and control of a rolling microrobot. The microrobot is capable of manipulating micro-objects through the use of a magnetic visual control system. This system consists of a rod-shaped microrobot, a magnetic actuation system and a visual control system. Motion of the rolling microrobot on a supporting surface is induced by a rotating magnetic field. As the robot is submerged in a liquid this motion creates a rising flow in front, a sinking flow behind, and a vortex above the robot, thus enabling non-contact transportation of micro-objects. Besides this fluidvortex approach, the microrobot is also able to manipulate micro-objects via a pushing strategy. We present the design and modelling of the 50×60×300 µm micro-agent, the visual control system, and an experimental analysis of the micromanipulation and control methods.

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Intravitreal therapy is the most common treatment for many chronic ophthalmic diseases, such as age-related macular degeneration. Due to the increasing worldwide demand for intravitreal injections, there exists a need to render this medical procedure more time- and cost-efficient while increasing patient safety. The authors propose a medical assistive device that injects medication intravitreally. Compared to the manual intravitreal injection procedure, an automated device has the potential to increase safety for patients, decrease procedure times, allow for integrated data storage and documentation, and reduce costs for medical staff and expensive operating rooms. This work demonstrates the development of an assistive injection system that is coarsely positioned over the patient's head by the human operator, followed by automatic fine positioning and intravitreal injection through the pars plana. Several safety features, such as continuous eye tracking and iris recognition, have been implemented. The functioning system is demonstrated through ex vivo experiments with porcine eyes. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:752-762.].