Magnetoelectric micromachines with wirelessly controlled navigation and functionality

Chen, Xiang‐Zhong; Shamsudhin, Naveen; Hoop, Marcus; Pieters, Roel; Siringil, Erdem; Sakar, Mahmut Selman; Nelson, Bradley J.; Pané, Salvador

doi:10.1039/c5mh00259a

Cited by 68 publications

(56 citation statements)

References 53 publications

(68 reference statements)

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“…39,44 Here, the Au coated Ni-nanotubes filled with Chi were immersed in DI water and magnetic fields were applied. In our proposed multifunctional drug delivery system, targeted locomotion is accomplished due to the ferromagnetic properties of the Ni carrier.…”

Section: Resultsmentioning

confidence: 99%

A smart multifunctional drug delivery nanoplatform for targeting cancer cells

et al. 2016

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Wirelessly guided magnetic nanomachines are promising vectors for targeted drug delivery, which have the potential to minimize the interaction between anticancer agents and healthy tissues. In this work, we propose a smart multifunctional drug delivery nanomachine for targeted drug delivery that incorporates a stimuli-responsive building block. The nanomachine consists of a magnetic nickel (Ni) nanotube that contains a pH-responsive chitosan hydrogel in its inner cavity. The chitosan inside the nanotube serves as a matrix that can selectively release drugs in acidic environments, such as the extracellular space of most tumors. Approximately a 2.5 times higher drug release from Ni nanotubes at pH = 6 is achieved compared to that at pH = 7.4. The outside of the Ni tube is coated with gold. A fluorescein isothiocyanate (FITC) labeled thiol-ssDNA, a biological marker, was conjugated on its surface by thiol-gold click chemistry, which enables traceability. The Ni nanotube allows the propulsion of the device by means of external magnetic fields. As the proposed nanoarchitecture integrates different functional building blocks, our drug delivery nanoplatform can be employed for carrying molecular drug conjugates and for performing targeted combinatorial therapies, which can provide an alternative and supplementary solution to current drug delivery technologies.

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Section: Resultsmentioning

confidence: 99%

A smart multifunctional drug delivery nanoplatform for targeting cancer cells

et al. 2016

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“…Material demonstrations of such particulate micromachines include core-shell nanoparticles composed of ferromagnetic and magnetostrictive FeGa cores surrounded by ferroelectric and piezoelectric polymeric shells [31], piezoelectric polymeric matrices containing magnetic nanoparticles [32,33], and ceramic ferrimagnetic CoFe 2 O 4 / ferroelectric BaTiO 3 composite nanoparticles [34,35]. Mouse tests have shown that the latter can be magnetically guided across the blood-brain barrier, and that they do not cause toxicity or behavioral impairment [36], suggesting promise in treating traumatic neuronal injuries or degenerative diseases via delivery of drugs or neural progenitor cells and through cell stimulation [31].…”

Section: B Bio-medical Applications: Magnetic-field Control Of Electmentioning

confidence: 99%

Multiferroics beyond electric-field control of magnetism

Spaldin

2020

Proc. R. Soc. A.

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Multiferroic materials, with their combined and coupled magnetism and ferroelectricity, provide a playground for studying new physics and chemistry as well as a platform for the development of novel devices and technologies. Based on my July 2017 Royal Society Inaugural Lecture, I review recent progress and propose future directions in the fundamentals and applications of multiferroics, with a focus on initially unanticipated developments outside of the core activity of electric-field control of magnetism.

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“…For example, Chen et al recently developed Janus micromachines, which were halfcoated with CoFe2O4. The magnetically anisotropic coating allowed for the rolling motion of the Janus micromachines on a surface under rotating magnetic fields [76].…”

Section: Chatzipirpiridis Et Al Fabricated Such Structures By Electrmentioning

confidence: 99%

Recent developments in magnetically driven micro- and nanorobots

Chen

Hoop

Mushtaq

et al. 2017

Applied Materials Today

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325

205

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Micro-and nanorobots are promising devices for biomedical and environmental applications. The past few years have witnessed rapid developments in this field. This short review intends to address recent progress on magnetically driven micro-and nanorobots developed in our laboratory and by other research groups. Different designs such as helical swimmers, flexible swimmers, surface walkers, and others are categorized and discussed. Specific applications of these robots in the fields of biomedicine or environmental remediation are also reported. Finally, the use of magnetic fields for additional capabilities beyond manipulation is presented.

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Magnetoelectric micromachines with wirelessly controlled navigation and functionality

Abstract: A magnetoelectric micromachine manipulated by magnetic field for both locomotion and on-demand function triggering enlighten the concept of unisource-powered microdevices.

Cited by 68 publications

References 53 publications

A smart multifunctional drug delivery nanoplatform for targeting cancer cells

A smart multifunctional drug delivery nanoplatform for targeting cancer cells

Multiferroics beyond electric-field control of magnetism

Recent developments in magnetically driven micro- and nanorobots

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