Recebido em 22/12/2017. Aprovado em 20/03/2018. RESUMOO objetivo deste estudo foi avaliar a sala de aula invertida como estratégia de ensino-aprendizagem para o conteúdo abertura coronária. O material didático para estudo prévio individual pelos estudantes foi disponibilizado online por meio de um software/aplicativo para desktop e dispositivos móveis contendo textos, imagens e vídeos demonstrativos. Nas aulas presenciais, o estudo prévio foi avaliado por um teste individual e em grupos houve discussão das respostas individuais monitorada pelo professor. Em seguida, foi apresentado um caso-problema, acompanhado de questões a serem resolvidas. Houve discussão das respostas até o entendimento e solução do problema apresentado. Vídeos com a sequência dos procedimentos para abertura coronária de elementos dentários simulados foram projetados antes e durante a execução da prática laboratorial. Por meio das respostas dos questionários de expectativa e de avaliação do método, 92,8% concordaram ser um método adequado para o aprendizado do tema proposto, apesar da maioria (64,2%) reconhecer que teriam dificuldades para o domínio do conteúdo. Após a atividade laboratorial, 100% dos estudantes estavam satisfeitos e confirmaram que o método contribuiu para o seu aprendizado. Além disso, 92,8% concordaram que a estratégia de ensino superou as expectativas e que estavam motivados para outras experiências. Os dados da autoavaliação de aquisição de competências pré e pós sala de aula invertida comprovaram que houve aprendizado significativo pelos estudantes e todos foram considerados habilitados baseados nos dados após a observação das habilidades pelo professor. Concluiu-se que a estratégia da sala de aula invertida foi adequada para o estudo do conteúdo abertura coronária. Descritores: Educação. Ensino. Aprendizagem por Associação de Pares. Endodontia.

Objective: This work aimed of to review the implications of anti-TNF-α therapy in COVID-19 patients associated with the genetic polymorphism (TNF-α polymorphisms in the region-308) of this pertinent cytokine  Methodology: Electronic searches were carried out on PUBMED Central, BVS/BIREME, Web of Science and The Cochrane Library with the aid of key-words. Results: Twenty-six articles were collected. Anti-TNF-α therapy was interpreted and evaluated. Conclusions: Although scarce information is available in the current literature, anti- TNF-α therapy seems to be a viable clinical approach for hospitalized COVID-19 patients who do not need oxygen supply. The genetic polymorphisms, although relevant, may be useful for further researched to assess the clinical response in different research groups.

Objective: This study aimed to carry out a literature review to describe the clinical characteristics of Monkeypox, explain its means of transmission, and favor its prevention. Methodology: Searches using descriptors in PUBMED Central, BVS/BIREME, Web of Science, Scielo, The Cochrane Library, Google Scholar, and books on the subject, classified as gray literature. Results: During the review process on the therapeutic options available for the treatment and prevention of the disease, it can be concluded that the population's access to efficient health has become essential, so that there is effective control of this disease, through vaccination, prevention programs, and information to the population about the means of transmission.

Objetivo: Descrever as principais características dos psicopatas, incluindo seus hábitos sexuais no ritual de encanto, domínio e abandono de suas vítimas, bem como explicar o caos e a devastação que causam nelas. Por fim, sugerir abordagens de tratamento para as vítimas no processo de recuperação dos danos. Metodologia: Foram realizadas entrevistas com vítimas de psicopatas que conviveram com eles por mais de uma década. As informações concernentes aos hábitos sexuais foram cuidadosamente categorizadas e explicadas. Como suporte, buscas on-line para a construção deste artigo foram realizadas, nas bases de dados do Google Acadêmico, PUBMED Central, Web of Science, BVS/BIREME, Science Direct, Scielo, The Cochrane Library e também pela PROSPERO. As identidades das vítimas e dos psicopatas foram mantidas em sigilo. Resultados: Os hábitos sexuais dos psicopatas incluem 3 fases: bombardeamento de amor inicial, humilhação, dominação da vítima e, finalmente, o abandono após exploração sexual, emocional e financeira. As principais consequências na vida dos parceiros incluem caos, distúrbios do sono e da alimentação, raiva, desespero e depressão, e em alguns casos levar à morte. Conclusões: A psicopatia não possui tratamento, e devido à devastação que causa nas pessoas pelo sentimento de traição, exploração e ausência de amor, faz com que as vítimas tenham todos os aspectos da sua vida destruídos. A única forma de combater é através do conhecimento da mente psicopata e do que eles podem fazer.

Objective: To describe the main characteristics of psychopaths including their sexual habits in their ritual of charming, dominating, and abandoning their victims, as well as explain the chaos and devastation they cause in them. Finally, suggest treatment approaches for victims in the damage recovery process. Methodology: Interviews were conducted with victims of psychopaths who lived with them for more than a decade. Information concerning sexual habits was carefully categorized and explained. As support, online searches for the construction of this article were carried out in the databases of Google Scholar, PUBMED Central, Web of Science, BVS / BIREME, Science Direct, Scielo, The Cochrane Library, and also by PROSPERO. The identities of victims and psychopaths were kept confidential. Results: The sexual habits of psychopaths include 3 stages: initial love bombing, humiliation, and domination of the victim, and finally abandonment after sexual, emotional, and financial exploitation. The main consequences in the lives of partners include chaos, sleep and eating disorders, anger, despair, and depression, and in some cases lead to death. Conclusions: psychopathy has no treatment, and due to the devastation, it causes in people due to the feeling of betrayal, exploitation, and lack of love, it causes victims to have all aspects of their lives destroyed. The only way to fight it is through knowing the psychopath's mind and what they can do.

Aim: To establish a protocol for patients medicated with bisphosphonates, through literature review, to avoid osteonecrosis and to provide professional guidance to accomplish the appropriate treatment. Methodology: On line searches were accomplished for the construction of this paper, which included as databases Web of Science, PUBMED Central, BVS/BIREME, Science Direct, The Cochrane Library and also PROSPERO. Results: The following characteristics were observed in the research of this protocol: Drugs with antireabsorption properties, RANK-L Inhibitor, Antiangiogenic agents, Clinical Manifestations, Drug-related risk factors, Local risk factors to be observed, Systemic and demographic risk factors, High risk factors considered. Conclusions: Bisphosphonates may be a helpful therapy for patients with organic consequences related to the therapy applied with them. Appropriate anamnesis and assessment of the systemic conditions for patients using them are mandatory requirements before their prescription.

This literature review addresses monkeypox, an infectious disease caused by the Monkeypox virus that belongs to the genus Orthopoxvirus and to the family Poxviridae, the same as the human smallpox virus. It had its first case registered in Congo in 1970. After almost 40 years, with no reported case, in 2017 it re-emerged in Nigeria. With the absence of mass vaccination and its transmission occurring through direct contact with people infected through close and prolonged exposure to droplets or other respiratory secretions, this virus has already originated in more than 44 countries, causing a new global pandemic. With a low mortality rate, which can reach between 3% and 6%, its symptoms are very similar to those observed in patients with smallpox, although they are clinically less severe. Thus, the present work aimed to study the characteristics and general aspects of monkeypox, in order to take measures to prevent and promote this disease.

Objective: To evaluate the bond strength of repairs with the self-adhering flowable composite Vertise Flow (Kerr) and a conventional composite resin Filtek Z350 (3M ESPE) subjected to different surface treatments. Methods: Forty specimens were divided into four groups: ZV (Filtek Z350 + Vertise Flow, without prior treatment); ZAV (Z350 + Vertise Flow with prior treatment with Single Bond Universal Adhesive System (3M ESPE)); ZAZ (Filtek Z350 + Filtek Z350 with prior treatment with Single Bond Universal Adhesive System (3M ESPE)); VV (Vertise Flow + Vertise Flow, without prior treatment). After 15 days of storage, the specimens were subjected to microtensile tests (Kratos IKCL3-USB, SP, Brazil), with speed of 0.5 mm/min and 20kg load. For statistical analysis, ANOVA with Tukey tests were used (p < 5%). Results: The mean values of the bond strength were highest respectively in the groups: ZV (36.07 ± 37.63); ZAZ (24.04 ± 28.51); VV (19.39 ± 28.24) and ZAV (16.06 ± 15.66). The bond strength of the repairs between the groups presented satisfactory results. Conclusion: The self-adhesive composite resin Vertise Flow seems to be a viable and fast alternative for composite resins repairs.