Studies on the structural specificity of kinetin have demonstrated that a variety of 6-(substituted)aminopurines and 6-(substituted)thiopurines, even with an additional 2-fluoro or 2-amino substituent, replace kinetin in several biological systems. It was of considerable interest to investigate further the specificity of the imidazole ring by preparing a group of 4-(substituted)pteridines. That the pteridine ring cannot replace the purine ring with retention of activity is indicated by the inactivity of these compounds in stimulating the rate of lettuce seed germination either in the presence or in the absence of gibberellic acid.
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