BackgroundThe present study was carried out to prepare multi-herbal combination via comparing antioxidant activity and polyphenolic composition of five medicinal plant extracts of Punica granatum L., Putranjiva roxburghii Wall., Swertia chirata Buch.-Ham., Tinospora cordifolia (Willd.) Miers and Trigonella corniculata L.MethodsThe herbs were individually evaluated using in vitro antioxidant assays and analyzed by HPLC-PDA. The resultant data was examined using principal component analysis (PCA). Further, herbal combination was prepared on the basis of PCA.ResultsThe PCA divided the plants into three groups. The leading or primary group contained P. granatum and P. roxburghii with the highest antioxidant activity strongly correlated with high amount of kaempferol. S. chirata was acknowledged as nourisher herb in one and T. cordifolia and T. corniculata were identified as stimulator herbs in other group. The herbal combination exhibited high antioxidant activity as compared to the individual plants. The combination revealed good antiproliferative efficacy against hepatocellular carcinoma (HepG2) cells with IC50 of 75.864 μg/ml.ConclusionsThe activity observed in vitro with HepG2 cells suggests that the herbal combination can provide therapeutic activity in vivo in future. The study may provide information regarding precise preparation of multi-herbal formulations using PCA as a tool in pharmaceutical industries.Electronic supplementary materialThe online version of this article (10.1186/s12906-019-2432-9) contains supplementary material, which is available to authorized users.
The use of technology is very important nowadays. Most of everyday activities are documented and stored in digital form. One of those activity is recording. Activity of an organization is very important, therefore recording of meeting material is one of those important activities. Usually the meeting material is documented by writing them into papers or typing them and stored them into computer. Sometimes, the meeting information is written or typed incorrectly so a speech-to-text application is required to solve this problem. In this study, the solution offered is to implement a web-based automation speed-to-text application which can record the voice of meeting participants then converted them into text automatically, so the results of the recording process of meeting materials are more effective and efficient By using voice recognition feature its called web kit Speech Recognition, this system can be implemented. After successfully implementing this application which is so called Speech Meeting Web kit system, the average value for duration system for Indonesia and English language is 96,63 % and 82,78 %.
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