The addition of ifosfamide to cisplatin, doxorubicin, and methotrexate did not enhance EFS or overall survival for patients with osteosarcoma. The addition of MTP to chemotherapy resulted in a statistically significant improvement in overall survival and a trend toward better EFS.

The addition of ifosfamide in this dose schedule to standard chemotherapy did not enhance EFS. The addition of MTP to chemotherapy might improve EFS, but additional clinical and laboratory investigation will be necessary to explain the interaction between ifosfamide and MTP.

The infrared emission limb sounder MIPAS (Michelson Interferometer for Passive Atmospheric Sounding) will be operated as an ESA core instrument on the ENVISAT-1 satellite. Near real time retrieval of pressure, temperature (p,T) and volume mixing ratio (VMR) of six key species (O 3 , H 2 O, HNO 3 , CH 4 , N 2 O and NO 2 ) from calibrated spectra will be performed in the Level 2 processor of the ENVISAT Payload Data Segment. An ESA supported study was carried out for the development of an optimized (with respect to speed and accuracy) retrieval algorithm suitable for the implementation in MIPAS Level 2 processor. In the framework of this study, an optimized forward / retrieval code was implemented based on the global fit approach. In this approach all the spectra of a limb-scanning sequence are simultaneously fitted in order to correctly account for error correlations in the altitude domain. Besides, only spectral intervals which are sensitive to the retrieved parameters are analyzed by using a microwindow approach. This also minimizes interferences of spectral signatures from atmospheric species with unknown concentration. Finally, a sequential retrieval of the target species VMR profiles is performed. The trade-off between run time and accuracy of the retrieval was optimized from both the physical and mathematical point of view, with optimizations in the program structure, in the radiative transfer model and in the computation of the retrieval Jacobian. The attained performances of the retrieval code are: noise error on temperature < 2 K at all the altitudes covered by the typical MIPAS scan (8-53 km with 3 km resolution), noise error on tangent pressure < 3 % , noise error on VMR of the target species < 5 % at most of the altitudes covered by the standard MIPAS scan. The run-time required to perform p,T and VMR retrieval of the five MIPAS target species from a limb-scanning sequence of 16 limb-views is less than 1 minute on a modern work-station.

We assessed the outcome of children with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) receiving contemporary risk-based therapy by evaluating clinical and biologic features and outcome of children with ALL, with or without DS, enrolled in Children's Cancer Group (CCG) protocols between 1983 and 1995. Comparison of characteristics of children with ALL with (ALL-DS; n ‫؍‬ 179) or without (ALL-NDS; n ‫؍‬ 8268) DS showed no differences in initial white blood cell (WBC) count, central nervous system disease, and risk group. Children with ALL-DS did not present with unfavorable translocations and were older than 1 year of age at diagnosis with ALL. Eventfree (56% vs 74%; P < .001) and diseasefree (55% vs 73%; P < .001) survival at 10 years was significantly lower in the standard-risk ALL-DS population compared with ALL-NDS, but not in high-risk ALL-DS population (event-free survival, 62% vs 59%; P ‫؍‬ .9; disease-free survival, 64% vs 59%; P ‫؍‬ .9), and these differences persisted regardless of treatment era (early era [1983][1984][1985][1986][1987][1988][1989] vs recent era [1989][1990][1991][1992][1993][1994][1995]

Non-skin (group 2) EML appeared to be an independent favorable prognostic factor. Localized radiotherapy to the site of EML at the end of induction chemotherapy did not improve outcome.

This study describes skeletal, neuromuscular and fitness impairments among 109 children (median age 10 (range 4–18) years, 65.1% male, 63.3% white) with acute lymphoblastic leukemia (ALL), enrolled on a physical activity trial from 2009 to 2013. Outcomes were measured 7-10 days after diagnosis and compared to age- and sex-specific expected values. Associations between function and HRQL were evaluated with logistic regression. Children low values for BMD z-scores/height (mean±standard error: −0.53±0.16 vs. 0.00±0.14, p <0.01), body mass index percentile (57.6±3.15 vs. 50.0±3.27%, p=0.02), quadriceps strength (201.9±8.3 vs. 236.1±5.4 Newtons, p<0.01), six minute walk distance (385.0±13.1 vs. 628.2±7.1 meters, p < 0.001), and Bruininks-Oseretsky Test of Motor Proficiency (23±2.5 vs. 50±3.4%, p < 0.001). Quadriceps weakness was associated with a 20.9-fold (95% CI 2.5–173.3) increase in poor physical HRQL. Children with newly diagnosed ALL have weakness and poor endurance and may benefit from early rehabilitation that includes strengthening and aerobic conditioning.

Differential scanning calorimetry (DSC), FTIR, X‐ray diffraction (XRD), and viscosity methods were used to examine the miscibility, interaction, and degradability of cationic guar gum (GG) and sodium carboxymethylcellulose (NaCMC) in their blend films. The experiment results prove that there exist electrostatic interactions and hydrogen bonding between GG and NaCMC. Blend films degrade quicker than pure GG or NaCMC film. Furthermore, the degradation rate of blend films is related to the interactions between GG and NaCMC. Based on the research of blend films as the drug carriers for Ibuprofen, it is found that the blend composition, initial drug concentration, and pH value affect the drug release and the GG/NaCMC blend films have good sustained release performance. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 3553–3559, 2007

These results suggest that children who receive CRT and ITC are at risk for problematic peer relations, particularly if they are male or younger at diagnosis. Given the stability of poor peer relationships and documented linkages between peer problems and subsequent academic and psychiatric difficulties, clinical services should address these issues. Research is needed to identify mechanisms that account for these outcomes and provide direction for prevention and treatment efforts.