Sixteen definite cases of NBTE were found in a series of 6,459 autopsies. Eight of these cases had multiple large valvular vegetations; 4 had a single large vegetation and 4 disclosed multiple small vegetations. Seven of the 8 cases with the multiple large vegetations had mucus producing carcinoma, clinically significant infarctions of various organs due to emboli from the NBTE and clinical or autopsy evidence of peripheral venous thrombosis. This combination of clinicopathologic findings appears to constitute a definite, though uncommon syndrome, and retrospective review of the patients' charts suggests that it may be possible to establish this diagnosis during life.
A series of groups of Sprague-Dawley rats were given either secobarbital, phenobarbital, morphine, pentazocine, diazepam, methotrimeprazine, or saline (control) intraperitoneally on 4 consecutive days and then, on day 5, anesthetized with chloroform, trichlorethylene, fluroxene, halothane, methoxyflurane, enflurane, isoflurane, bromotrifluorocyclobutane, or chlorotrifluorocyclobutane. One control group received neither pretreatment nor anesthetics and another was given pretreatment but no anesthetics. The factor of "enzyme induction" is also evaluated, as are SGPT elevation and liver and kidney lesions. If enzyme induction occurred with the drugs used for pretreatment, the anesthetics suppressed the expected response. SGPT levels were generally within normal range. The combinations of all pretreatments with enflurane, halothane, or methoxyflurane had the fastest recovery; recovery was slower with the other anesthetic agents, but none of the prior chemotherapeutic drugs accelerated recovery from the inhalation anesthetics.
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