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With roots in ancient formulations, methods for the chemical derivatization of proteins continue to expand and develop. The creation of this new journal dealing exclusively with bioconjugate chemistry was barely conceivable just a few years ago. An explosion of interest in the subject during the last decade is, however, easily seen. The tremendous growth in both the number of publications and in the number of research groups involved in these kinds of studies has been promoted by both practical interests related, for example, in some cases to possible pharmacological or medical diagnostic applications and by interest in questions of fundamental biochemical structure and function.Greatly Reagents have been designed to preserve electrostatic charge (4,5), to alter electrostatic charge (6), and to increase hydrophobicity (7,8). Reagents and procedures have been developed to decrease immunogenicity (9, 20), to increase and decrease susceptibility to proteolysis (22-23), to increase UV or visible absorbancy (14), to introduce fluorescent labels (25,16), spin labels (27), radiolabels , various metal ions (22), magnetic microspheres (22,23), and electron-dense substituents (24), to increase the content of certain low-abundance nonradioactive isotopes (25)

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