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HighlightsMediastinal paragangliomas are extremely rare and their diagnosis and management can be challenging.These tumors are classified as functional or non-functional according to their ability to produce and release catecholamines.Appropriate laboratory studies should be done prior to biopsy or surgical resection to avoid complications.Complete surgical resection continues to be the standard of care for patients diagnosed with mediastinal paraganglioma.Surgeons must consider catecholamine-secreting tumors as a differential diagnosis of mediastinal lesions.

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