Immunization is one of the most cost-effective public health measures as it has helped in huge reduction of disease, disability and death from different infectious diseases in children by protecting them from vaccine preventable diseases. The current study aimed to study factors associated with dropout for pentavalent vaccine in tertiary care hospital of Kathmandu. A longitudinal observational study using purposive sampling technique was conducted among 196 infants. The information was obtained using self-constructed structured questionnaire from parents visiting Community Medicine OPD of Nepal Medical College Teaching Hospital. The information regarding socioeconomic characteristics of mother, gender of the infant, place of delivery of child, birth order and reasons for dropout of pentavalent third dose were taken. The dropout of third dose pentavalent vaccine was mainly seen in infant of parents living in rented house and according to gender wise, dropout was high among male infants. The different reasons for dropout of vaccine were busy parents, forgotten date, visit to other immunization centres and sick infants. Among these, the main reason for dropout of vaccine was due to infants getting sick during the time of immunization. The dropout rates between first and third dose of pentavalent vaccine were 26.3% and 30.4% respectively for two consecutive months and the overall dropout rate was 28.35%. Also, literacy level of the mother was directly associated with the immunization visit of the infant as, maximum number of infants of illiterate mother were absent for third dose of pentavalent vaccine as opposed to no absentee among master degree holding mothers. Thus, the present study provides valuable information regarding the factors associated with dropout for pentavalent vaccine.
Background: Various studies have shown that low body mass index co-relates with the severity of Chronic obstructive pulmonary disease. The reduced body mass index in these patients is thought to be due to nutritional abnormality and raised circulating inflammatory markers. The study is aimed to find the association of body mass index with respiratory failure in patient with chronic obstructive pulmunory disease.Methods: 142 patients who attended emergency /out-patient-department in Sir Sundarlal Hospital from August 2018 to July 2020 were enrolled for the study. 81 patients in one group had chronic obstructive pulmonary disease exacerbation with Type II respiratory failure. Among this group low and normal body mass index subgroup was categorized.61 patients in another group had chronic obstructive pulmonary disease. Non-invasive ventilation was applied to case group. Categorization of body mass index was done <18.5(Low BMI) and 18.5-24.9 (Normal BMI ). Results: The mean age of the study group was (63.53±9.021). There was a significant difference in the body mass index between the groups ( p=<0.001,t=15.40). Severity of respiratory failure was compared using ph and pco2 in the between the groups which showed no significant difference (p=1,chi square 0.000), (p=0.40,chi square=0.72) however it did affect the outcome.Conclusions: Our study shows that overall respiratory failure was common in low body mass index cases compared to Control. Nevertheless there was no difference among severity of respiratory failure among low and normal body mass index subgroups and however it did affect the outcome.Keywords: Brain natriuretic peptide; chronic obstructive pulmonary diseases; non-invasive ventilation
In Nepal the prevalence of hypertension is in increasing trend with an increased number of deaths from heart disease and stroke. The morbidity and mortality from hypertension, cardiovascular disease and other chronic diseases has been associated with high Body mass index (BMI). The current study aimed to study the association between BMI, blood pressure and age of the adults in Makalbari area. A community based cross-sectional study was conducted among 643 respondents. The information was obtained using self constructed structured questionnaire which included demographic information of individuals. Height, weight and blood pressure were recorded and hypertension was defined as per Joint National Committee (JNC) VII guidelines. Maximum value of mean BMI was found among 40-49 years age group. BMI was found to be lowest among younger age group. Both the mean systolic and diastolic BP were found to be lowest among the youngest age groups. Mean Systolic BP increased steadily with age and the highest value was found among the oldest age group. Mean Diastolic BP increased with age till 40-49 years and declined thereafter. There was significant (P <0.01) positive correlation of BMI with systolic and diastolic BP. It showed that BP increased with increase in BMI. Correlation coefficient showed that relationship of BMI with systolic BP (0.231) was stronger than diastolic BP (0.167). Thus the present study provides valuable information regarding the association of BMI with systolic and diastolic blood pressure. It also showed the correlation of blood pressure with increasing age independently.
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