In this study, we examined the perceptions of Ghanaians about COVID-19 vaccines and the factors that may influence their intentions to vaccinate. We conducted an online survey to collect data from 331 Ghanaians, between 22nd March 2021 and 15th April 2021. Descriptive multivariate analyses were performed using STATA version 13. The findings revealed that 45.7% of respondents were reluctant to vaccinate even if the vaccines were available for free. Age, region and residential area were significant predictors of intention to vaccinate. Misinformation, side effects and lack of trust were among some reasons cited for not intending to vaccinate. However, some people were likely to vaccinate when they were encouraged by a trusted community leader. To ensure higher uptake of vaccines, government officials must engage trusted community leaders to increase public education, targeting specific age groups, areas and regions in Ghana.
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