BACKGROUND: Down syndrome is a chromosome 21 disorder and the most common cause of physical abnormalities including midface hypoplasia, facial hypotonia, and also drooling. Drooling is unintentional anterior salivary flow from the mouth. The objectives of the study is to determine and analyze the effects of midfacial hypoplasia and facial hypotonia on drooling in Down syndrome children. Subject and method: METHODS: of the research is analytic correlational. Sample retrievement using purposive sampling technique and obtained 20 samples that fulfills the inclusive criterias, consisting of 13 boys and 7 girls with an age range of 6 to 16 years old. RESULTS AND DISCUSSION: The results were tested statistically by Kendall Coefficient of Concordance Test and Spearman Coefficient of Rank Correlation Test. The results showed that the effect of midfacial hypoplasia, facial hypotonia at rest, and during clenching on drooling is very significant (p-value 0.0002) with Kendall Coefficient of Concordance. Spearman Coefficient of Rank Correlation test results show correlation of midface hypoplasia on drooling is not significant (p-value 0,1265). Facial hypotonia at rest has a very significant correlation on drooling (p-value 0,0000) and during clenching also has a very significant correlation (p-value 0,0000). CONCLUSION: Conclusion of the research is there are effects of midface hypoplasia, facial hypotonia at rest and facial hypotonia during clenching on drooling, also facial hypotonia at rest and facial hypotonia during clenching on drooling, but no effect of midface hypoplasia on drooling in Down syndrome children.
Latar belakang: kondisi kesehatan umum anak dapat diketahui melalui pengukuran indeks masa tubuh atau body mass indeks (BMI). BMI dapat digunakan sebagai sarana penilaian malnutrisi dengan membandingkan berat badan dan tinggi badan anak menurut usia. BMI memiliki hubungan dengan kondisi kesehatan mulut anak yang ditandaidengan indeks OHI-S yang secara signifikan memiliki hubungan erat dengan indeks def-t. Tujuan: tujuan penelitianini adalah untuk mengetahui korelasi antara BMI dan def-t anak usia sekolah dasar di Kabupaten Bandung. Metode:penelitian ini merupakan penelitian deskriptif dengan menggunakan metode cross sectional. Sampel penelitian adalah228 siswa sekolah dasar berusia 5-9 tahun dengan ketentuan tidak memiliki sejarah penyakit sistemik. BMI ditentukan dengan mengukur berat badan dan tinggi badan anak disesuaikan dengan usia, sedangkan indeks karies ditentukan dengan menghitung def-t berdasarkan karakterisasi WHO. Hasil: BMI anak laki-laki adalah 14,47±1,96, BMI anak perempuan adalah 14,62±1,74 sedangkan rata-rata def-t adalah 8,84. Penghitungan korelasi dengan menggunakan Spearman rank didapat nilai p korelasi adalah 0,350 (p0,05), hal ini menunjukkan tidak terdapat hubungan yangsignifikan antara def-t dengan BMI. Penghitungan korelasi Spearman rank untuk BMI dan def-t berdasarkan gendermemperlihatkan nilai p untuk anak laki-laki adalah 0,385 (p0,05) dan anak perempuan adalah 0,738 (p0,05),hal ini menunjukkan tidak terdapat korelasi yang signifikan antara BMI dan def-t baik pada anak laki-laki maupunperempuan. Kesimpulan: hasil penelitian menunjukkan tidak terdapat korelasi antara BMI dan def-t baik pada anaklaki-laki maupun pada anak perempuan usia sekolah dasar di Kabupaten Bandung
Background: Estrogen plays a key role in human physiological processes. Polymorphisms of estrogen receptors have been implicated in the development of numerous diseases. The aim of this study was to evaluate the frequency of ERα gene Pvull and Xbal polymorphisms and assessing their association with CD4+ T-cell counts in HIV-infected children on highly active antiretroviral therapy. Methods: CD4+ T cell counts were determined using the FACS count system. ERα PvuII and XbaI polymorphisms were analyzed by PCR-RFLP. Results: This study enrolled 34 HIV-infected children on HAART. The frequencies of the PvuII and XbaI gene polymorphisms were PP 41,2%, Pp 26,5%, pp 32,4% and XX 35,3%, Xx 17,6%, xx 47,1% respectively. CD4+ T-cell counts were significantly associated with XbaI polymorphisms (p<0.05), but not PvuII polymorphisms (p>0.01). Discussion: Host genetic factor polymorphism is an important determinant of HIV disease progression and treatment response. The ERα Pvull and Xbal polymorphisms can increase risk for the development of HIV-related complication, including oral diseases. Conclusion: The ERα gene XbaI polymorphism was significantly associated with CD4+ T-cell counts. It may explain the role of estrogen in the regulation of HIV replication. Studying human genetic variation in HIV-infected individuals is important to guide a new therapeutic approach.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.